Apomorphine subcutaneous infusion, duodenal infusion of levodopa and deep brain stimulation – three advanced treatment options for the advanced Parkinson’s disease

  • Dušan Flisar University Clinical Center Ljubljana Neurology Clinic
  • Nina Zupančič Križnar University Clinical Center Ljubljana Neurology Clinic
  • Maja Trošt University Clinical Center Ljubljana Neurology Clinic
  • Zvezdan Pirtošek University Clinical Center Ljubljana Neurology Clinic
Keywords: Parkinson’s disease, apomorphine subcutaneous infusion, duodenal infusion of levodopa, deep brain stimulation

Abstract

Advanced stage of Parkinson's disease is associated with motor complications: motor fluctuations and dyskinesias. The disease can no longer be satisfactorily treated with oral therapy that is based on treatment with levodopa. Dying of dopamine neurons, a short half-life of levodopa and pulsatile stimulation of dopamine receptors are the main reasons for these complications. Currently, there are three options available to treat the advanced stage of Parkinson's disease: subcutaneous infusion of apomorphine, intrajejunal infusion of levodopa and deep brain stimulation. It is necessary to choose the optimal method of treatment that is most suitable for the individual patient.

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Author Biographies

Dušan Flisar, University Clinical Center Ljubljana Neurology Clinic
Dušan Flisar, MD
Nina Zupančič Križnar, University Clinical Center Ljubljana Neurology Clinic
Nina Zupančič Križnar, MD
Maja Trošt, University Clinical Center Ljubljana Neurology Clinic
Assist. Prof. Maja Trošt, MD, PhD
Zvezdan Pirtošek, University Clinical Center Ljubljana Neurology Clinic
Prof. Zvezdan Pirtošek, MD, PhD

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Published
2016-08-29
How to Cite
1.
Flisar D, Zupančič Križnar N, Trošt M, Pirtošek Z. Apomorphine subcutaneous infusion, duodenal infusion of levodopa and deep brain stimulation – three advanced treatment options for the advanced Parkinson’s disease. ZdravVestn [Internet]. 29Aug.2016 [cited 17Sep.2019];85(7-8). Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/1402