Intrauterine insemination – analysis and comparison of cycles stimulated with clomiphene citrate or gonadotrophins
AbstractBackground: The purpose of our study was to determine the success rate of IUI depending on type of stimulation. We tried to establish the influence of infertility indications and semen quality on IUI cycle outcome. Methods: We analyzed retrospectively 1753 cycles performed in 781 infertile patients. We compared the success rate depending on indication, type of stimulation and semen quality. For statistical analysis Pearson’s chi-square and Mann- Whitney U tests were used. Results: Pregnancy rate was 6.6 % for all indications, pregnancy rate per couple was 13.6 %. Pregnancy rate for idiopathic infertility was 7.6 %, for female infertility, male infertility and combination of the two the rates were 6.5 %, 5.4 % and 5.0 % respectively. The lowest pregnancy rate 3.4 % per cycle was achieved in couples with tubal infertility. Pregnancy rate with clomiphene citrate stimulation was 6.3 % and with gonadotrophins 10 %; 87 % of pregnancies were achieved when inseminated with semen that contained at least 2 million mobile sperm. Conclusions: IUI is a noninvasive, low-cost method. It is suitable for the treatment of idiopathic infertility, male infertility and female infertility without tubal pathology. The best results are obtained in cycles stimulated with gonadotrophins and with total motile sperm count of at least two million per catheter.
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.