Acute retroviral syndrome in Slovenian patients infected with HIV

  • Mateja Pirš
  • Janez Tomažič
  • Mario Poljak
  • Dunja Z. Babič
Keywords: HIV, acute HIV syndrome

Abstract

Background: Two to six weeks after primary infection with HIV 50 to 90 percent of patients develop an acute retroviral syndrome which usually presents with mononucleosis or flu-like illness. Due to nonspecific symptoms ARS is frequently misdiagnosed.

Patients and methods: Data of Slovenian patients with acute retroviral syndrome is shown, as well as their symptoms, approaches to management and diagnostic particularities of primary HIV infection.

Conclusions: The combination of particular symptoms and epidemiological data should lead us to consider the possibility of an early HIV infection.

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References

Kassutto S, Rosenberg ES. Primary HIV type 1 infection. Clin Infect Dis 2004; 38: 1447–53.

Marolt-Gomišček M. Sindrom pridobljene imunske pomanjkljivosti – aids. In: Marolt-Gomišček M, Radšel-Medvešček A. Infekcijske bolezni. 2. izdaja. Ljubljana: Tangram; 2002. p. 443–70.

UNAIDS (2004). AIDS epidemics update. December 2004. Geneva, UNAIDS.

Klavs I, Kastelic Z. Prijavljeni primeri aidsa in okužbe s HIV v Sloveniji od 1.1.1986 do 30.11.2004. Poročilo št. 4/2004. Ljubljana: Inštitut za varovanje zdravja Republike Slovenije, 2004: 1–4.

Pilcher CD, Shugars DC, Fiscus SA, Miller WC, Menezes P, Giner J, et al. HIV in body fluids during primary HIV infection: implications for pathogenesis, treatment and public health. AIDS 2001; 15: 837–45.

Kahn JO, Walker BD. Acute human immunodeficiency virus type 1 infection. N Engl J Med 1998; 339: 33–9.

Lavreys L, Baeten JM, Overbaugh J, Panteleeff DD, Chohan BH, Richardson BA, et al. Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan women. Clin Infect Dis 2002; 35: 77–81.

Hecht FM, Busch MP, Rawal B, Webb M, Rosenberg E, Swanson M, et al. Use of laboratory tests and clinical symptoms for identification of primary HIV infection. AIDS 2002; 16: 1119–29.

Vanhems P, Lambert J, Cooper DA, Perrin L, Carr A, Hirschel B, et al. Severity and prognosis of acute human immunodeficiency virus type 1 illness: a dose-response relationship. Clin Infect Dis 1998; 26: 323–9.

Mellors JW, Kingsley LA, Rinaldo CR Jr, Todd JA, Hoo BS, Kokka RP, Gupta P. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995; 122: 573–9.

Pincus JM, Crosby SS, Losina E, King ER, LaBelle C, Freedberg KA. Acute human immunodeficiency virus infection in patients presenting to an urban urgent care center. Clin Infect Dis 2003; 37: 1699–704.

Luft S, Seme K, Poljak M. Laboratory diagnosis of human immunodeficiency virus infection. Acta Dermatovenerol Alp Pannon Adriat 2004; 13: 43–9.

Weber B, Fall EH, Berger A, Doerr HW. Reduction of diagnostic window by new fourth-generation human immunodeficiency virus screening assays. J Clin Microbiol 1998; 36: 2235–9.

Rosenberg ES, Altfeld M, Poon SH, Phillips MN, Wilkes BM, Eldridge RL, et al. Immune control of HIV-1 after early treatment of acute infection. Nature 2000; 407: 523–6.

Busch MP, Satten GA. Time course of viremia and antibody seroconversion following human immunodeficiency virus exposure. Am J Med 1997; 102: 117–24.

Murthy KK, Henrard DR, Eichberg JW, Cobb KE, Busch MP, Allain JP, Alter HJ. Redefining the HIV-infectious window period in the chimpanzee model: evidence to suggest that viral nucleic acid testing can prevent bloodborne transmission. Transfusion 1999; 39: 688–93.

Poljak M, Babič D, Seme K. Retrospective evaluation of the Vidas HIV DUO test for simultaneous detection of anti-HIV antibody and p24 antigen. Acta Dermatovenerol Alp Pannon Adriat 2002; 11: 11–3.

Weber B, Meier T, Enders G. Fourth generation human immunodeficiency virus (HIV) screening assays with an improved sensitivity for p24 antigen close the second diagnostic window in primary HIV infection. J Clin Virol 2002; 25: 357–9.

Weber B, Berger A, Rabenau H, Doerr HW. Evaluation of a new combined antigen and antibody human immunodeficiency virus screening assay, VIDAS HIV DUO Ultra. J Clin Microbiol 2002; 40: 1420–6.

Centers for Disease Control. Revised guidelines for HIV counseling, testing, and referral. Morb Mortal Wkly Rep 2001; 50(RR-19): 1–58.

Poljak M, Seme K, Koren S. Sodobna diagnostika okužbe s HIV. In: Zbornik predavanj I. kliničnega simpozija o aidsu. Ljubljana: Medicinski razgledi 1997: 21–45.

Fidler S, Oxenius A, Brady M, Clarke J, Cropley I, Babiker A, et al. Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection. AIDS 2002; 16: 2049–54.

How to Cite
1.
Pirš M, Tomažič J, Poljak M, Babič D. Acute retroviral syndrome in Slovenian patients infected with HIV. ZdravVestn [Internet]. 1 [cited 22Nov.2019];74(6). Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/2119
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Professional article