Colorectal cancer in Slovenia – differences in surgical treatment and patient survival

  • Gregor Norčič
  • Stane Repše
  • Vera Pompe-Kirn
Keywords: colorectal cancer, surgery, stage at diagnosis, survival, epidemiological (population) study


Background: Colorectal cancer (CRC) is one of the most frequent malignant diseases in Slovenia. Its incidence rises constantly in the last years while the outcome of treatment is poorer than in other developed countries.

Methods: In a retrospective study we analysed 940 colorectal cancer patients diagnosed in Slovenia in 1997.

Results: Differences in outcome between the Slovenian institutions are due to different stage-distributions and differences in surgical radicality. Differences in pathohistological staging and medical oncological treatment are probably less important. The same can be said regarding some of the examples from abroad.

Conclusions: With constant and objective auditing, the improvement of all aspects of treatment can be achieved, resulting in better survival of all Slovenian colorectal cancer patients.


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Incidenca raka v Sloveniji 1997. Ljubljana: Onkološki inštitut, Register raka za Slovenijo, poročilo št. 39; 2000.

Incidenca raka v Sloveniji 2002. Ljubljana: Onkološki inštitut, Register raka za Slovenijo, poročilo št. 44; 2005.

Pompe-Kirn V, Zakotnik B, Zadnik V, Serša G. Preživetje bolnikov z rakom 1983–1997. Ljubljana: Onkološki inštitut; 2003

Coleman MP, Gatta G, Verdecchia A, Esteve J, Sant M, Storm H, et al. EUROCARE-3 summary: cancer survival in Europe at the end of the 20th century. Ann Oncol 2003; 14 Suppl 5: 128–49.

Norčič G. Vpliv stadija bolezni ob pričetku zdravljenja na preživetje bolnikov z rakom debelega črevesa in danke v Sloveniji (magistrska naloga). Ljubljana: Univerza v Ljubljani; 2005.

Hermanek P Jr, Wiebelt H, Riedl S, Staimmer D, Hermanek P. Long-term results of surgical therapy of colon cancer. Results of the Colorectal Cancer Study Group. Chirurg 1994; 65: 287–97.

Jagoditsch M, Lisborg PH, Jatzko GR, Wette V, Kropfitsch G, Denk H, et al. Long-term prognosis for colon cancer related to consistent radical surgery: multivariate analysis of clinical, surgical, and pathologic variables. World J Surg 2000; 24: 1264–70.

Jatzko GR, Jagoditsch M, Lisborg PH, Denk H, Klimpfinger M, Stettner HM. Long-term results of radical surgery for rectal cancer: multivariate analysis of prognostic factors influencing survival and local recurrence. Eur J Surg Oncol 1999; 25: 284–91.

Faivre-Finn C, Bouvier-Benhamiche AM, Phelip JM, Manfredi S, Dancourt V, Faivre J. Colon cancer in France: evidence for improvement in management and survival. Gut 2002; 51: 60–4.

Koyama Y, Kotake K. Overview of colorectal cancer in Japan: report from the Registry of the Japanese Society for Cancer of the Colon and Rectum. Dis Colon Rectum 1997; 40 Suppl 10: 2–9.

Hermanek P, Wittekind C. Residual tumor (R) classification and prognosis. Semin Surg Oncol 1994; 10: 12–20.

Schrag D, Cramer LD, Bach PB, Cohen AM, Warren JL, Begg CB. Influence of hospital procedure volume on outcomes following surgery for colon cancer. JAMA 2000; 284: 3028–35.

Weitz J, Koch M, Friess H, Buchler MW. Impact of volume and specialization for cancer surgery. Dig Surg 2004; 21: 253–61.

Komuta K, Batts K, Jessurun J, Snover D, Garcia-Aguilar J, Rothenberger D, et al. Interobserver variability in the pathological assessment of malignant colorectal polyps. Br J Surg 2004; 91: 1479–84.

Schlemper RJ, Itabashi M, Kato Y, Lewin KJ, Riddell RH, Shimoda T, et al. Differences in the diagnostic criteria used by Japanese and western pathologists to diagnose colorectal carcinoma. Cancer 1998; 82: 60–9.

Miller EA, Woosley J, Martin CF, Sandler RS. Hospital-to-hospital variation in lymph node detection after colorectal resection. Cancer 2004; 10:1065–71.

Feinstein AR, Sosin DM, Wells CK. The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med 1985; 312: 1604–8.

Shahrier M, Ahnen DJ. Colorectal cancer survival in Europe: the Will Rogers phenomenon revisited. Gut 2000; 47: 463–4.

Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Goodman PJ, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 1990; 322: 352–8.

Saltz LB, Minsky B. Adjuvant therapy of cancers of the colon and rectum. Surg Clin North Am 2002; 82: 1035–58.

How to Cite
Norčič G, Repše S, Pompe-Kirn V. Colorectal cancer in Slovenia – differences in surgical treatment and patient survival. ZdravVestn [Internet]. 1 [cited 22Sep.2019];74(12). Available from:
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