• Janez Zidar Institute of Clinical Neurophysiology Medical Centre Ljubljana Zaloška cesta 7 1525 Ljubljana Slovenia
Keywords: neuromuscular centre, diagnosis, treatment, counselling


Main functions of a neuromuscular (NM) centre are making diagnosis, treatment and counselling. Some other functions, e. g. forming a register and epidemiological endeavours, could be added. All these activities are expected to be achieved by multidisciplinary approach with the idea that members use the same guidelines and share the same knowledge.

NM diseases affect lower levels of the nervous system that is motor units (motor cells in the brainstem and spinal cord, nerve roots, cranial and peripheral nerves, neuromuscular junction, and muscles). There are many such diseases; a few are more common others are rare.

Rational approach in making a diagnosis can be divided into several steps. The process begins with a person with clinical symptoms and signs which raise the suspicion of NM disease. The first step is the description of the predominant pattern of muscular wasting and weakness (e. g. limb-girdle, distal, ocular, facio-scapulo-humeral). Each of these syndromes require a differential diagnosis within the motor unit territory what is achieved by means of EMG and muscle biopsy. The latter is even more important to define the nature of the abnormality. Disease nature can also be determined biochemically and, as NM disorders are commonly genetically determined, at the molecular genetic level. Treatment modalities include drugs (causative and symptomatic) and other measures such as promoting and maintaining good general health, preventing skeletal deformities, physiotherapy, orthoses, surgery, and prevention of respiratory and cardiac functions. Counselling is mainly by social workers that focus on the practical aspects of coping with illness and disability and by genetic counsellors who gave advise on family planning.


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Bulcke JAL, Baert AL. Clinical and radiological aspects of myopathies. CT scanning, EMG, radioisotopes. Berlin, Heidelberg, New York: SpringerVerlag, 1982: 1–187.

Detels R, McEwen J, Beaglehole R, Tanaka H eds. Oxford textbook of public health. Vol. I. 4th ed. Oxford, New York: Oxford University Press, 2002: 1–414.

Emery AEH. Muscular dystrophy. The facts. 2nd ed. New York: Oxford University Press, 2000: 1–166.

Mastaglia FL, Laing NG. Investigation of muscle disease. J Neurol Neurosurg Psychiatry 1996; 60: 256–74.

Reilly MM, Hanna MG. Genetic Neuromuscular disease. J Neurol Neurosurg Psychiatry 2002; 73: Suppl II: ii12–21.

Ringel SP. Neuromuscular disorders. A guide for patient and family. New York: Raven Press, 1987: 1–153.

How to Cite
Zidar J. FUNCTIONS OF A NEUROMUSCULAR CENTRE. ZdravVestn [Internet]. 1 [cited 3Apr.2020];73. Available from:
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