PROCALCITONIN AND INTERLEUKIN-6 AS MARKERS OF SEVERE INFECTION IN CHILDREN WITH FEBRILE NEUTROPENIA

  • Lidija Kitanovski Služba za onkologijo in hematologijo Pediatrična klinika Klinični center Vrazov trg 1 1525 Ljubljana
  • Meta Derganc Klinični oddelek za otroško kirurgijo in intenzivno terapijo Klinični center Zaloška 7 1525 Ljubljana
  • Janez Jazbec Služba za onkologijo in hematologijo Pediatrična klinika Klinični center Vrazov trg 1 1525 Ljubljana
  • Majda Benedik Dolničar Služba za onkologijo in hematologijo Pediatrična klinika Klinični center Vrazov trg 1 1525 Ljubljana
  • Jožica Anžič Služba za onkologijo in hematologijo Pediatrična klinika Klinični center Vrazov trg 1 1525 Ljubljana
  • Marija Gubina Inštitut za mikrobiologijo in imunologijo Medicinska Fakulteta Zaloška 4 1000 Ljubljana
  • Sergej Hojker Klinika za nuklearno medicino Klinični center Zaloška 7 1525 Ljubljana
  • Blaž Krhin Klinika za nuklearno medicino Klinični center Zaloška 7 1525 Ljubljana
Keywords: febrile neutropenia, child, infection, procalcitonin, interleukin-6

Abstract

Background. The results of the study conducted to determine whether procalcitonin (PCT) and interleukin-6 (IL-6) are more sensitive and specific markers of severe infection in children with febrile neutropenia (FN) than routinelly used C-reactive protein (CRP) are presented in the article. 68 episodes of FN experienced by 32 patients were divided into three groups according to the site of infection. Group 1: episodes of bacteraemia and/or clinical sepsis (n = 16), group 2: episodes of focal infection (n = 16) and group 3: episodes of fever of unknown origin (FUO) (n = 36). Blood samples for further PCT and IL-6 determination were collected on three consecutive days. CRP concentrations were measured daily in each patient until the resolution of fever. PCT, IL-6 and CRP concentrations were measured on one occassion in each of the 18 afebrile patients with malignant disase forming the reference group. Serum PCT and IL-6 concentrations were measured by immunochemiluminometric and immunoenzymatic assay. Receiver Operating Characteristic (ROC) curves were used to determine optimum sensitivity, specificity, positive and negative predictive values and diagnostic accuracy of the studied parameters.

Conclusions. PCT and IL-6 were found to be earlier and more sensitive markers of severe infection in neutropenic patients than CRP. The erliest one was IL-6, followed by PCT and CRP. Sequential determination of PCT up to 72 hours improved its diagnostic value, which was not the case for IL-6.In patients with gramnegative bacteraemias PCT concentracions were 3–5 times higher comparing to grampositive, whereas IL-6 concentrations were comparable in both groups.

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How to Cite
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Kitanovski L, Derganc M, Jazbec J, Benedik Dolničar M, Anžič J, Gubina M, Hojker S, Krhin B. PROCALCITONIN AND INTERLEUKIN-6 AS MARKERS OF SEVERE INFECTION IN CHILDREN WITH FEBRILE NEUTROPENIA. ZdravVestn [Internet]. 1 [cited 19Oct.2019];73. Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/2453
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