EPSTEIN-BARR VIRUS INFECTIONS – AVIDITY TEST FOR IgG ANTIBODIES

  • Katja Strašek Inštitut za mikrobiologijo in imunologijo Medicinske fakultete v Ljubljani, Zaloška 4, 1000 Ljubljana
  • Jožica Marin Inštitut za mikrobiologijo in imunologijo Medicinske fakultete v Ljubljani, Zaloška 4, 1000 Ljubljana
Keywords: Epstein-Barr virus, diagnosis, avidity, avidity index, IgG antibodies

Abstract

Background. We wish to introduce specific IgG avidity test as a supplementary assay in serological screening for Epstein-Barr virus infection if the status of patient cannot be resolved from a single serum sample with routine testing.
Methods. Avidity of IgG antibodies was determined in sera of 57 patients with different stage of Epstein-Barr virus infection. Enzyme-immuno assay was used with a short incubation of 6-molar urea included in the procedure. Urea should remove low avidity antibodies. Avidity was expressed as the avidity index. Avidity testing with commercial kit was done as well.
Results. Low avidity index was found for IgG antibodies of acute phase sera and high for those of past infection, recent infection and reactivation of endogenic virus.
Conclusions. Avidity test for IgG antibodies might be supplementary assay to prove acute infection but also to resolve some other clinical states related to Epstein-Barr virus.

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Published
2017-04-16
How to Cite
1.
Strašek K, Marin J. EPSTEIN-BARR VIRUS INFECTIONS – AVIDITY TEST FOR IgG ANTIBODIES. ZdravVestn [Internet]. 16Apr.2017 [cited 22Sep.2019];70(6). Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/2565
Section
Case report, short scientific article