Radiolabelled peptides in nuclear medicine
Nuclear medicine plays an important role in the management of oncology patients. It enables visualization and localization of tumours, targeted radionuclide therapy and monitoring patient response to therapy. Highly specific peptide molecules can target tumour cells with overexpressed receptors for regulatory peptides and their analogues. When these peptides are radiolabelled we can use them either for diagnosis or therapy, depending on the radionuclide used. These theranostic pairs enable nuclear medicine a personalized approach to patient management. Classical example of theranostic pairs are radiolabelled somatostatin analogues that are routinely used in diagnosis and targeted radionuclide therapy of neuroendocrine neoplasms (NEN). On the other hand, radiolabelled minigastrin analogues can be used for diagnosis of metastatic medullary thyroid carcinoma (MTC) and have a potential to be used also in targeted radionuclide therapy. The purpose of this review is to describe the overview of radiolabelled peptides and to present two theranostic systems used in nuclear medicine.
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