Unstable scar as a chronic wound and the possibility of Marjolin ulcer onset
DOI:
https://doi.org/10.6016/ZdravVestn.2850Keywords:
ulcer, burn, wound, surgery, carcinomaAbstract
Marjolin ulcer is a rare, highly aggressive type of squamous cell carcinoma. It emerges from chronic wound after a burn. Our goal was to point out the danger of malignant transformation of an unstable scar as a chronic wound (Marjolin ulcer) and possible options of treatment in our hospital and other hospitals in the world. At the University Medical Centre Ljubljana, Clinical Department of Plastic, Reconstructive, Aesthetic Surgery and Burns in the last 13 years we operated on 5 patients due to an unstable burn scar manifested as a chronic wound. We reviewed English literature on the topic of ulceration of the unstable chronic scar.
Marjolin ulcer is a preventable epithelioma alteration. Every large wound that is left for secondary healing has a potential to develop into a chronic wound that can ulcerate and change into a malignant lesion. This is most often seen in burns and scars. If chronic wound has developed, biopsy and treatment are needed. Treatment was most effective when done as soon as possible and when there was no malignant alteration of the wound.
Downloads
References
1. Tiftikcioglu YO, Ozek C, Bilkay U, Uckan A, Akin Y. Marjolin ulcers arising on extremities. Ann Plast Surg. 2010;64(3):318-20.
DOI: 10.1097/SAP.0b013e3181a73064
PMID: 20179482
2. Yu N, Long X, Lujan-Hernandez JR, Hassan KZ, Bai M, Wang Y, et al. Marjolin’s ulcer: a preventable malignancy arising from scars. World J Surg Oncol. 2013;11(1):313.
DOI: 10.1186/1477-7819-11-313
PMID: 24341890
3. Kerr-Valentic MA, Samimi K, Rohlen BH, Agarwal JP, Rockwell WB. Marjolin’s ulcer: modern analysis of an ancient problem. Plast Reconstr Surg. 2009;123(1):184-91.
DOI: 10.1097/PRS.0b013e3181904d86
PMID: 19116552
4. Pekarek B, Buck S, Osher L. A Comprehensive Review on Marjolin’s Ulcers: diagnosis and Treatment. J Am Col Certif Wound Spec. 2011;3(3):60-4.
DOI: 10.1016/j.jcws.2012.04.001
PMID: 24525526
5. Huang CY, Feng CH, Hsiao YC, Chuang SS, Yang JY. Burn scar carcinoma. J Dermatolog Treat. 2010;21(6):350-6.
DOI: 10.3109/09546630903386580
PMID: 20438387
6. Gül U, Kiliç A. Squamous cell carcinoma developing on burn scar. Ann Plast Surg. 2006;56(4):406-8.
DOI: 10.1097/01.sap.0000200734.74303.d5
PMID: 16557073
7. Ozek C, Cankayali R, Bilkay U, Guner U, Gundogan H, Songur E, et al. Marjolin’s ulcers arising in burn scars. J Burn Care Rehabil. 2001;22(6):384-9.
DOI: 10.1097/00004630-200111000-00006
PMID: 11761388
8. Copcu E. Marjolin’s ulcer: a preventable complication of burns? Plast Reconstr Surg. 2009;124(1):156e-64e.
DOI: 10.1097/PRS.0b013e3181a8082e
PMID: 19568055
9. Fishman JR, Parker MG. Malignancy and chronic wounds: marjolin’s ulcer. J Burn Care Rehabil. 1991;12(3):218-23.
DOI: 10.1097/00004630-199105000-00004
PMID: 1885637
10. Saaiq M, Ashraf B. Marjolin’s ulcers in the post-burned lesions and scars. World J Clin Cases. 2014;2(10):507-14.
DOI: 10.12998/wjcc.v2.i10.507
PMID: 25325060
11. Bozkurt M, Kapi E, Kuvat SV, Ozekinci S. Current concepts in the management of Marjolin’s ulcers: outcomes from a standardized treatment protocol in 16 cases. J Burn Care Res. 2010;31(5):776-80.
DOI: 10.1097/BCR.0b013e3181eed210
PMID: 20661151
12. Shawn RS, Glenn G, Howard GR, Kimberly KH. Dermatol Surg. 2004;30:229-30.
DOI: 10.1111/j.1524-4725.2004.30072.x
PMID: 14756658
13. Eser A, Serkan Y, Tayfun A. Is surgery an effective and adequate treatment in advanced Marjolin's ulcer? Burns journal. 2005;31(4):421-31.
DOI: 10.1016/j.burns.2005.02.008
PMID: 15896503
Downloads
Published
Issue
Section
License
The Author transfers to the Publisher (Slovenian Medical Association) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Slovenian Medical Association) has the right to transfer the rights of acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.