CHRONIC INFLAMMATION AND CARCINOGENESIS: AN EXAMPLE OFCOLORECTAL CANCER IN INFLAMMATORY BOWEL DISEAS
AbstractBACKGROUND Inflammatory bowel diseases, ulcerative colitis and Crohn’s disease, are a very heterogenous group of diseases. The basis is an inapropriate immune response of the bowel mucosato environmental factors in genetically predisposed persons. Incidence of inflammatorybowel disease is increasing in the developed countries and in Slovenia also. Patients withcolitis lasting more than 10 years are at an increased risk of colorectal cancer. Chronicinflammation of the bowel mucosa is believed to be the main factor influencing colorectalcancer risk. CONCLUSIONS Colorectal cancer carcinogenesis is a complex, long-lasting multistep process. Despiteintense research in this field there is still no objective marker which would help us inpredicting clinical course of inflammatory bowel disease and identify patients with thehighest risk for colorectal cancer development. In this paper we review some of the knowncharacteristics of chronic inflammation in the bowel mucosa, their molecular and geneticfeatures and possible associations with carcinogenesis
The Author transfers to the Publisher (Zdravniški vestnik/Slovenian Medical Journal) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Zdravniški vestnik/Slovenian Medical Journal) has the right to transfer the rights, acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.