USAGE OF MODELLING AND SIMULATION IN MEDICINE AND PHARMACY
AbstractBACKGROUND Modelling and simulation have become established methodology in explanation, analysisand prediction of systems operation and can therefore be met practically in all scientificdisciplines including medicine and pharmacy. In spite of the fact that even in these twoareas the nature of problems can differ drastically, developed methodology enables theusage of similar and systematically organised design techniques, where the cooperationwith problem experts is of crucial importance. CONCLUSIONS In the paper some aspects regarding modelling and simulation in medicine and pharmacyare described. First in the introduction the basic terminology and reasons for using modellingand simulation as problem – solving techniques are given. Further, the main methodologies,including cyclic modelling activities, approaches in model construction and modelrepresentations are presented. The section is ending with experimental part of model solving, where the main attention is devoted to the continuous simulation. Presented ideasare illustrated through several simple and comprehensible examples which can frequentlybe met in the field of medicine and pharmacy. At the end also one more complex problem isintroduced where predictive capabilities of modelling were illustrated for the study of influenceof obesity to five different diseases, where also existing cross-couplings were takeninto account. Modelling results have enabled economic evaluation of obesity treatmentand the prediction of needed hospitalization and expenses regarding the absence from thework. Modelling and simulation can also in medicine and pharmacy explain and throwlight upon complex clinical and therapeutic circumstances which can not be obtainedfrom the clinical and experimental research data
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