38-YEAR-OLD CHEESE-LOWER WITH SUSPECTED CEREBRAL VASCULITIS
Keywords:
chronic meningitis, neurobrucellosis, prosthetic joint infectionAbstract
Background. This study presents a 38-year-old patient who presented with a few weeks lasting headache, double vision, neck pain, nausea and vomiting, paresthesiae of her face and arms and aphasia. Patient’s physical and neurological examination on admission was unremarkable.
Results. Cerebrospinal fluid findings showed a lymphocytic pleocytosis and increased protein concentration with presence of oligoclonal banding. Magnetic resonance imaging of the head showed multiple subcortical lesions.
Conclusions. This study describes complications due to initial false diagnosis and discusses the differential diagnosis of chronic meningitis. As brucellosis usually presents in a very nonspecific manner, the diagnosis can be difficult. The primary pitfall is failure to consider possible infection with Brucella in a patient with history that suggests a possible source of infection. Therefore, a detailed history and knowledge of the patient exposures in the recent past is essential.
Downloads
References
Hauser SL, Goodkin DE. Multiple sclerosis and other demyelinating diseases. In: Braunwald E, Fauci AS, Isselbacher KJ et al eds. Harrison’s
principles of internal medicine. 15th ed. New York, NY: McGraw-Hill, 2001: 2452–61.
Vogt T, Hasler P. A woman with panic attacks and double vision who liked cheese. Lancet 1999; 354: 300–0.
Gripshover BM, Ellner JJ. Chronic meningitis. In: Mandell GL, Bennett JE, Dolin R eds. Principles and practice of infectious diseases. 5th ed. Philadelphia, PA: Churchill Livingstone, 2000: 997–1009.
McLean DR, Russell N, Khan MY. Neurobrucellosis: clinical and therapeutic features. Clin Infect Dis 1992; 15: 582–90.
Young EJ. Brucella species. In: Mandell GL, Bennett JE, Dolin R eds. Principles and practice of infectious diseases. 5th ed. Philadelphia, PA: Churchill Livingstone, 2000: 2386–93.
Akdeniz H, Irmak H, Anlar O, Demiroz AP. Central nervous system brucellosis: presentation, diagnosis and treatment. J Infect 1998; 36: 297–301.
Radšel-Medvešček A. Lymska borelioza. In: Marolt-Gomišček M, RadšelMedvešček A. Infekcijske bolezni. Ljubljana: Tangram, 2002: 225–34.
Radšel-Medvešček A. Bruceloza. In: Marolt-Gomišček M, Radšel-Medvešček A. Infekcijske bolezni. Ljubljana: Tangram, 2002: 175–9.
Kraigher A, Hočevar-Grom A, Klavs I, Sočan M et al. Epidemiološko spremljanje nalezljivih bolezni v Sloveniji v letu 2000. Zdrav Var 2001; 40: Suppl 4: 30–0.
Kavčič M, Korošec Ž. Laboratorijsko pridobljena okužba z bakterijo Brucella melitensis. Knjiga izvlečkov. 3. Slovenski kongres preventivne medicine, 17.–22. maj, 2002. Ljubljana: Sekcija za preventivno medicino SZD, Inštitut za varovanje zdravja, 2002: 10–0.
Shakir RA, Al Din AS, Araj GF, Lulu AR, Mousa AR, Saadah MA. Clinical categories of neurobrucellosis. A report on 19 cases. Brain 1987; 110: 213–23.
Ariza J, Corredoira J, Pallares R et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis 1995; 20: 1241–9.
Matar GM, Khneisser IA, Abdelnoor AM. Rapid laboratory confirmation of human brucellosis by PCR analysis of a target sequence on the 31-kilodalton Brucella antigen DNA. J Clin Microbiol 1996; 34: 477–8.
Solera J, Espinosa A, Martinez-Alfaro E et al. Treatment of human brucellosis with doxycycline and gentamicin. Antimicrob Agents Chemother 1997; 41: 80–4.
Navarro V, Solera J, Martinez-Alfaro E, Saez L, Escribano E, Perez-Flores JC. Brucellar osteomyelitis involving prosthetic extra-articular hardware. J Infect 1997; 35: 192–4.
Orti A, Roig P, Alcala R et al. Brucellar prosthetic arthritis in a total knee replacement. Eur J Clin Microbiol Infect Dis 1997; 16: 843–5.
Ortega-Andreu M, Rodriguez-Merchan EC, Aguera-Gavalda M. Brucellosis as a cause of septic loosening of total hip arthroplasty. J Arthroplasty 2002; 17: 384–7.
Malizos KN, Makris CA, Soucacos PN. Total knee arthroplasties infected by Brucella melitensis: a case report. Am J Orthop 1997; 26: 283–5.
Agarwal S, Kadhi SK, Rooney RJ. Brucellosis complicating bilateral total knee arthroplasty. Clin Orthop, 1991: 179–81.
Downloads
Issue
Section
License
The Author transfers to the Publisher (Slovenian Medical Association) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Slovenian Medical Association) has the right to transfer the rights of acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.