SHOCK SYNDROME IN A PATIENT WITH HYPOPITUITARISM DUE TO BRAIN TUMOR
DOI:
https://doi.org/10.6016/ZdravVestn.2280Keywords:
shock syndrome, hypopituitarism, brain tumorAbstract
Background. Shock syndrome is an acute tissue hypoperfusion. Early diagnosis and adequate symptomatic and causal treatment are mandatory. In spite of different etiologies (dehidration, bleeding, heart failure, sepsis), clinical signs and symptomes are similar (hypotension, tachicardia, tachipnoe, pallor, cold and wet skin, oliguria and metabolic acidosis). Rarely, the shock syndrome is the consequence of the adrenal insufficiency due to hypopituitarism caused by brain tumor where early treatment with hydrocortisone is urgent.
Methods. This article presents a patient with a shock syndrome and multiorgan failure. Endocrinological testing and brain CT demonstrated an endocrinologically inactive tumor of hypophysis. The tumor was growing into adjacent hypophyseal tissue and causing hypopituitarism with secondary hypothyroidism and adrenal insufficiency and deficit of both gonadotropins and growth hormone.
Conclusions. Primary or secondary adrenal insufficiency are among rare causes of shock syndrome. Whenever it is suspected, estimation of serum levels of cortisol and ACTH is necessary and immediate treatment with hydrocortisone should be instituted.
Downloads
References
Hollenberg SM, Parrillo JE. Shock. In: Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Fauci AS eds. Harrison’s principles of internal medicine. 14th edition on CD-ROM. New York: McGraw Hill, 1998.
Marino JP. The ICU book. Second edition. Philadelphia: Lippincott Williams & Wilkins, 1998: 228–59.
Biller BMK, Daniels GH. Neuroendocrine regulation and diseases of the anterior pituitary and hypothalamus. In: Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Fauci AS eds. Harrison’s principles of internal medicine. 14th edition on CD-ROM. New York: McGraw Hill, 1998.
Oelkers W. Adrenal insufficiency. N Engl J Med 1996; 335: 1206–12.
Arlt W, Allolio B. Adrenal insufficiency. The Lancet 2003; 361: 1881–93.
Bennett N, Gabrielli A. Hypotension and adrenal insufficiency. J Clin Anesth 1999; 11: 425–30.
Kaufmann P, Lax SF, Radner H, Eber B, Leuger A, Smolle KH. Severe hypotension and coma secondary to unrecognized chronic anterior hypophysitis. Intensive Care Med 1995; 10: 847–9.
Hazouard E, Piquemal R, Dequin PF, Tayoro J, Valat C, Legras A. Severe noninfectious circulatory shock related to hypopituitarism. Intensive Care Med 1999; 25: 865–8.
Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003; 348: 727–34.
Downloads
Issue
Section
License
The Author transfers to the Publisher (Slovenian Medical Association) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Slovenian Medical Association) has the right to transfer the rights of acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.