MULTIORGAN INJURY AFTER ACCIDENTAL POISONING WITH AUTUMN CROCUS

Authors

  • Gorazd Lešničar Oddelek za infekcijske bolezni in vročinska stanja Splošna bolnišnica Celje Oblakova ul. 5 3000 Celje
  • Lucija Gabršček Oddelek za intenzivno interno medicino Splošna bolnišnica Celje Oblakova ul. 5 3000 Celje
  • Bojan Krivec Oddelek za intenzivno interno medicino Splošna bolnišnica Celje Oblakova ul. 5 3000 Celje
  • Gorazd Voga Oddelek za intenzivno interno medicino Splošna bolnišnica Celje Oblakova ul. 5 3000 Celje
  • Branko Šibanc Oddelek za infekcijske bolezni in vročinska stanja Splošna bolnišnica Celje Oblakova ul. 5 3000 Celje
  • Janja Blatnik Oddelek za infekcijske bolezni in vročinska stanja Splošna bolnišnica Celje Oblakova ul. 5 3000 Celje
  • Boris Jagodič Javni zavod celjske lekarne Gregorčičeva ul. 5 3000 Celje

DOI:

https://doi.org/10.6016/ZdravVestn.2285

Keywords:

autumn crocus, wild garlic, colchicin poisoning, multiorgan injury

Abstract

Background. A case of accidental poisoning with autumn crocus (Colchicum autumnale) that was misinterpreted for wild garlic (Allium ursinum) is presented. Both plants grow on damp meadows and can be easily wrongly identified especially before blooming period as they have similar, pointed leaves.

Results. Considering anamnestic data, clinical picture and laboratory findings in 43-yr-old female, a poisoning with the colchicine plant alkaloid was suspected. Later, it was confirmed by toxicology analyses (chromatography and spectrometry) of the collected serum and urine samples. Severe initial gastrointestinal disorders progressed into ileus, bone-marrow suppression and multi-organ failure.

Conclusions. After the patient had received a symptomatic treatment with granulocyte-directed growth factor and a suitable antibiotic therapy for secondary infection, she recovered within three weeks from the onset of condition. The most persistent problem was alopecia. The disease did not entailed any permanent sequellae which was confirmed 3 years after the patient was considered cured.

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References

Pahlow M. Velika knjiga o zdravilnih rastlinah. Cankarjeva založba: Ljubljana, 1987: 86–7, 145–6.

Weakley-Jones B, Gerber JE, Biggs G. Colchicine poisoning – Case report of two homicides. Am J Forensic Med Pathol 2001; 22: 203–6.

Milne CT, Mech PD. Fatal colchicine overdose report of a case and review of the literature. Am Emerg Med 1998; 16: 603–8.

Wang RY, Morasco R, Glendon HC, Hoffman RS, Goldfrank RL. Antidotal efficacy of glutamate and aspartate for colchicine toxicity. Vet Human Toxicol 1997; 39: 207–10.

Borron SW, Scherrmann JM, Baud FJ. Markedly altered colchicine kinetics in a fatal intoxication: Examination of contributing factors. Human Exp Toxicol 1996; 15: 885–90.

Folpini A, Furfori P. Colchicine toxicity – Clinical features and treatment. Massive overdose. Case report. Clin Toxicol 1995; 33: 71–7.

Critchley JAJH et al. Granulocyte – colony stimulating factor in the treatment of colchicine poisoning. Human Exp Toxicol 1997; 16: 229–32.

Baud JF, Sabuoraut A, Vicaut E et al. Brief report: Treatment of severe colchicine overdose with colchicine-specific Fab fragments. N Engl J Med 1995; 332: 642–5.

Mery P, Riou B, Chemla D, Lecarpentier Y. Cardiotoxicity of colchicine in the rat. Intensive Care Med 1994; 20: 119–23.

Issue

Section

Professional Article

How to Cite

1.
MULTIORGAN INJURY AFTER ACCIDENTAL POISONING WITH AUTUMN CROCUS. ZdravVestn [Internet]. 2004 Apr. 25 [cited 2024 Nov. 2];73(4). Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/2285

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