Herpes simplex virus esophagitis in an immunocompetent child

Case report

Authors

  • Mateja Tiselj Community health centre Celje, Celje, Slovenia
  • Nina Zidar Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
  • Matjaž Homan Unit of Gastroenterology and Hepatology, Division of Paediatrics, University Medical Centre Ljubljana, Ljubljana, Slovenia

DOI:

https://doi.org/10.6016/ZdravVestn.2909

Keywords:

esophagitis, vomiting, herpes simplex, immunocompetence, acyclovir

Abstract

Herpes simplex oesophagitis is a condition that is rarely seen in immunocompetent patients, especially in childhood. However, it is important to also consider the condition in children with symptoms typical of the upper gastrointestinal tract, and to perform endoscopy to confirm the presence of HSV in the mucosa of the oesophagus. Medical management is only symptomatic while antiviral treatment can be added especially in childhood.

We present a case report of herpes simplex oesophagitis in a 9-year-old otherwise healthy boy who was admitted to our department with persistent vomiting and inability of oral food intake.

Clinical examination revealed pain in the lower abdomen on palpation and clinical signs of dehydration. In laboratory findings, inflammatory markers were mildly elevated.

After some basic examinations, we were not able to explain the child’s condition. The performed oesophagogastroduodenoscopy revealed inflammation. Biopsies of the oesophageal mucosa confirmed HSV type 1. Serology markers showed elevated IgM and normal IgG values while subsequent testing did not identify an immune disorder.

Downloads

Download data is not yet available.

References

1. Rodrigues F, Brandao N, Duque V, Ribeiro C, António AM. Herpes simplex virus esophagitis in immunocompetent children. J Pediatr Gastroenterol Nutr. 2004;39(5):560-3.
DOI: 10.1097/00005176-200411000-00022
PMID: 15572901

2. Lee B, Caddy G. A rare cause of dysphagia: herpes simplex esophagitis. World J Gastroenterol. 2007;13(19):2756-7.
DOI: 10.3748/wjg.v13.i19.2756
PMID: 17569149

3. Al-Hussaini AA, Fagih MA. Herpes simplex ulcerative esophagitis in healthy children. Saudi J Gastroenterol. 2011;17(5):353-6.
DOI: 10.4103/1319-3767.84496
PMID: 21912064

4. Kurahara K, Aoyagi K, Nakamura S, Kuwano Y, Yamamoto C, Iida M, et al. Treatment of herpes simplex esophagitis in an immunocompetent patient with intravenous acyclovir: a case report and review of the literature. Am J Gastroenterol. 1998;93(11):2239-40.
PMID: 9820405

5. Ramanathan J, Rammouni M, Baran J, Khatib R. Herpes simplex virus esophagitis in the immunocompetent host: an overview. Am J Gastroenterol. 2000;95(9):2171-6.
DOI: 10.1111/j.1572-0241.2000.02299.x
PMID: 11007213

6. Marinho AV, Bonfim VM, Rodrigues de Alencar L, Pinto SA, Alves de Araújo Filho J. Herpetic Esophagitis in Immunocompetent Medical Student. Case Rep Infect Dis. 2014;2014:930459.
DOI: 10.1155/2014/930459
PMID: 24707416

7. Canalejo E, Duran FG, Cabello N, Martinez JG. Herpes esophagitis in healthy adults and adolescents: report of three cases and review of the literature. Medicine (Baltimore). 2010;89(4):204-10.
DOI: 10.1097/MD.0b013e3181e949ed
PMID: 20616659

8. Wald A, Huang ML, Carrell D, Selke S, Corey L. Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture. J Infect Dis. 2003;188(9):1345-51.
DOI: 10.1086/379043
PMID: 14593592

9. Cronstedt JL, Bouchama A, Hainau B, Halim M, Khouqeer F, al Darsouny T. Spontaneous esophageal perforation in herpes simplex esophagitis. Am J Gastroenterol. 1992;87(1):124-7.
PMID: 1728108

10. Fritz J, Lerner D, Suchi M. Herpes Simplex Virus Esophagitis in Immunocompetent Children: A Harbinger of Eosinophilic Esophagitis? J Pediatr Gastroenterol Nutr. 2018;66(4):609-13.
DOI: 10.1097/MPG.0000000000001748
PMID: 28937540

Published

2020-04-30

How to Cite

1.
Herpes simplex virus esophagitis in an immunocompetent child: Case report. ZdravVestn [Internet]. 2020 Apr. 30 [cited 2024 Oct. 7];89(3-4):235-9. Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/2909