Diagnostics and treatment of enchondromas
DOI:
https://doi.org/10.6016/ZdravVestn.3226Keywords:
enchondroma, biopsy, incidental finding, BACTIP guidelinesAbstract
Enchondromas are benign intramedullary tumours of mature hyaline cartilage, accounting for 10–25% among all benign bone tumours.They are present in almost 3% of magnetic resonance examinations of knees and shoulders as an asymptomatic random finding. This paper presents epidemiology, clinical picture, imaging diagnostics, differential diagnostics, biopsy indications, histopathology, clinical monitoring, and treatment of enchondromas. Randomly discovered asymptomatic intramedullary solitary enchondromas in long bones mainly do not require treatment, as the risk of subsequent malignant alteration is less than 1%. Enchondromas in small bones of hands and feet are treated by excochleation biopsy due to a high risk of pathological fracture. Cartilaginous tumours exhibiting growth, local pain, or aggressive radiological characteristics require treatment at a tertiary facility with a possible biopsy and decision on observation/discharge/resection. The most complex clinical challenge is distinguishing common enchondromas from rare atypical cartilage tumors and even rarer chondrosarcomas, whereby the BACTIP guidelines can be very useful.
Downloads
References
1. Santini-Araujo E, Kalil RK, Bertoni F, Park YK, eds. Tumors and Tumor-Like Lesions of Bone: For Surgical Pathologists, Orthopedic Surgeons and Radiologists. London: Springer; 2015. pp. 243-51.
DOI: 10.1007/978-1-4471-6578-1
2. Nottrott M, Hardes J, Gosheger G, Andreou D, Henrichs M, Streitbuerger A. Benigne Knorpeltumoren. Was mache ich mit dem Zufallsbefund? Unfallchirurg. 2014;117(10):905-14.
DOI: 10.1007/s00113-014-2578-3
PMID: 25274388
3. Novak M, ur. 2. šola o sarkomih, Onkološki inštitut, Ljubljana. 13.9.2018; Ljubljana. Ljubljana: Sekcija za onkološko kirurgijo pri SZD; 2018.
4. Patel A, Davies AM, Botchu R, James S. A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee. Clin Radiol. 2019;74(7):517-26.
DOI: 10.1016/j.crad.2019.01.025
PMID: 30827492
5. Davies AM, Patel A, James SL, Botchu R. A retrospective validation of an imaging protocol for the management of solitary central cartilage tumours of the proximal humerus and around the knee. Clin Radiol. 2019;74(12):962-71.
DOI: 10.1016/j.crad.2019.08.017
PMID: 31587800
6. Jurik AG, Hansen BH, Weber K. Solitary enchondromas-diagnosis and surveillance : danish guidelines. Radiologe. 2020;60(S1):26-32.
DOI: 10.1007/s00117-020-00681-7
PMID: 32322923
7. Mavčič B. Smernice za obravnavo kostnih tumorjev v ortopedski ambulanti. Ljubljana: Slovensko zdravniško društvo. Združenje ortopedov; 2019 [cited 2021 Feb 11]. Available from: http://zdruzenje.ortopedov.si/wp-content/uploads/2019/12/Mavcic-B-2-Kostni-tumorji-smernice-29nov2019.pdf.
8. Hong ED, Carrino JA, Weber KL, Fayad LM. Prevalence of shoulder enchondromas on routine MR imaging. Clin Imaging. 2011;35(5):378-84.
DOI: 10.1016/j.clinimag.2010.10.012
PMID: 21872128
9. Walden MJ, Murphey MD, Vidal JA. Incidental enchondromas of the knee. AJR Am J Roentgenol. 2008;190(6):1611-5.
DOI: 10.2214/AJR.07.2796
PMID: 18492914
10. Haase SC. Treatment of pathologic fractures. Hand Clin. 2013;29(4):579-84.
DOI: 10.1016/j.hcl.2013.08.010
PMID: 24209955
11. Bloem JL, Reidsma II. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 2012;81(12):3793-801.
DOI: 10.1016/j.ejrad.2011.03.101
PMID: 21524868
12. Verdegaal SH, Bovée JV, Pansuriya TC, Grimer RJ, Ozger H, Jutte PC, et al. Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients. Oncologist. 2011;16(12):1771-9.
DOI: 10.1634/theoncologist.2011-0200
PMID: 22147000
13. Gaillard F, Weerakkody Y, Jones J, Alsalam HM, Stanislavsky A, Bashir U, et al. Enchondroma. Radiopaedia.org. S.l.: S.n.; 2020 [cited 2020 Dec 12]. Available from: https://radiopaedia.org/articles/enchondroma.
14. Enneking WF, Spanier SS, Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res. 1980;153:106-20.
DOI: 10.1097/00003086-198011000-00013
PMID: 7449206
15. Geirnaerdt MJ, Hogendoorn PC, Taminiau AH, Bloem JL. Malignant cartilage tumors. Radiologe. 1998;38(6):502-8.
DOI: 10.1007/s001170050385
PMID: 9700771
16. Bovée JV, Flanagan AM, Lazar AJ, Nielsen GP, Yoshida A. Bone tumours. In: ; World Health OrganizationWHO Classification of Tumours. Vol. 1. Digestive System Tumours. Geneva: WHO; 2020.
17. Jennings R, Riley N, Rose B, Rossi R, Skinner JA, Cannon SR, et al. An evaluation of the diagnostic accuracy of the grade of preoperative biopsy compared to surgical excision in chondrosarcoma of the long bones. Int J Surg Oncol. 2010;2010:270195.
DOI: 10.1155/2010/270195
PMID: 22312488
18. Bernard SA, Murphey MD, Flemming DJ, Kransdorf MJ. Improved differentiation of benign osteochondromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging. Radiology. 2010;255(3):857-65.
DOI: 10.1148/radiol.10082120
PMID: 20392983
19. Wittig J. Enchondroma. Morristown: Morristown Medical Center; 2014 [cited 2020 Dec 12]. Available from: http://www.tumorsurgery.org/tumor-education/bone-tumors/types-of-bone-tumors/enchondroma.aspx.
20. Mavrogenis AF, Gambarotti M, Angelini A, Palmerini E, Staals EL, Ruggieri P, et al. Chondrosarcomas revisited. Orthopedics. 2012;35(3):e379-90.
DOI: 10.3928/01477447-20120222-30
PMID: 22385450
21. Biondi NL, Varacallo M. Enchondroma. StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
Downloads
Published
Issue
Section
License
The Author transfers to the Publisher (Slovenian Medical Association) all economic copyrights following form Article 22 of the Slovene Copyright and Related Rights Act (ZASP), including the right of reproduction, the right of distribution, the rental right, the right of public performance, the right of public transmission, the right of public communication by means of phonograms and videograms, the right of public presentation, the right of broadcasting, the right of rebroadcasting, the right of secondary broadcasting, the right of communication to the public, the right of transformation, the right of audiovisual adaptation and all other rights of the author according to ZASP.
The aforementioned rights are transferred non-exclusively, for an unlimited number of editions, for the term of the statutory
The Author can make use of his work himself or transfer subjective rights to others only after 3 months from date of first publishing in the journal Zdravniški vestnik/Slovenian Medical Journal.
The Publisher (Slovenian Medical Association) has the right to transfer the rights of acquired parties without explicit consent of the Author.
The Author consents that the Article be published under the Creative Commons BY-NC 4.0 (attribution-non-commercial) or comparable licence.