Endometriosis management after menopause
DOI:
https://doi.org/10.6016/ZdravVestn.3420Keywords:
endometriosis, menopause, malignant transformation, oestrogen, menopausal hormone therapyAbstract
Endometriosis is a disease that can affect 2-5% of all postmenopausal women. It is a disease in which the glands and stroma of the uterus are located outside the maternity area. To date, little is known in the literature about endometriosis in menopausal women. Diagnostic concerns currently relate mainly to concerns about possible malignancy. Reports in the literature describe the recurrence of endometriosis in the postmenopausal period as well as the occurrence of endometriosis de novo. The treatment of choice for symptomatic endometriosis in menopause is the surgical removal of all visible endometriotic tissue, as the risk of recurrence and conversion to malignancy is relatively high. Postmenopausal hormone therapy (MHT) is often used to relieve postmenopausal symptoms and prevent bone loss. There are studies showing that MHZ can reactivate endometriotic foci and even promote malignant transformation of foci in women with a history of endometriosis. Considering the risks of MHZ in patients, which are not fully known, special caution should be exercised with this therapy.
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References
1. Guy JM, Edgar H. Edgar Haydon (1859-1942): general practitioner and radium pioneer. J Med Biogr. 2009;17(3):127-34.
DOI: 10.1258/jmb.2009.009015
PMID: 19723958
2. Janssen EB, Rijkers AC, Hoppenbrouwers K, Meuleman C, D’Hooghe TM. Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update. 2013;19(5):570-82.
DOI: 10.1093/humupd/dmt016
PMID: 23727940
3. Dowlut-McElroy T, Strickland JL. Endometriosis in adolescents. Curr Opin Obstet Gynecol. 2017;29(5):306-9.
DOI: 10.1097/GCO.0000000000000402
PMID: 28777193
4. Tan DA, Almaria MJ. Postmenopausal endometriosis: drawing a clearer clinical picture. Climacteric. 2018;21(3):249-55.
DOI: 10.1080/13697137.2018.1450855
PMID: 29609503
5. Jeon DS, Kim TH, Lee HH, Byun DW. Endometriosis in a postmenopausal woman on hormonal replacement therapy. J Menopausal Med. 2013;19(3):151-3.
DOI: 10.6118/jmm.2013.19.3.151
PMID: 25371883
6. Palep-Singh M, Gupta S. Endometriosis: associations with menopause, hormone replacement therapy and cancer. Menopause Int. 2009;15(4):169-74.
DOI: 10.1258/mi.2009.009041
PMID: 19933470
7. Haas D, Chvatal R, Reichert B, Renner S, Shebl O, Binder H, et al. Endometriosis: a premenopausal disease? Age pattern in 42,079 patients with endometriosis. Arch Gynecol Obstet. 2012;286(3):667-70.
DOI: 10.1007/s00404-012-2361-z
PMID: 22562384
8. Asencio F, Ribeiro HA, Ribeiro PA, Malzoni M, Adamyan L, Ussia A, et al. Symptomatic endometriosis developing several years after menopause in the absence of increased circulating estrogen concentrations: A systematic review and seven case reports. Gynecol Surg. 2019;3:16.
DOI: 10.1186/s10397-019-1056-x
9. Streuli I, Gaitzsch H, Wenger JM, Petignat P. Endometriosis after menopause: physiopathology and management of an uncommon condition. Climacteric. 2017;20(2):138-43.
DOI: 10.1080/13697137.2017.1284781
PMID: 28286987
10. Giannella L, Marconi C, Di Giuseppe J, Delli Carpini G, Fichera M, Grelloni C, et al. Malignant Transformation of Postmenopausal Endometriosis: A Systematic Review of the Literature. Cancers (Basel). 2021;13(16):4026.
DOI: 10.3390/cancers13164026
PMID: 34439184
11. Cumiskey J, Whyte P, Kelehan P, Gibbons D, Gibbons D. A detailed morphologic and immunohistochemical comparison of pre- and postmenopausal endometriosis. J Clin Pathol. 2008;61(4):455-9.
DOI: 10.1136/jcp.2007.050971
PMID: 17908802
12. Morotti M, Remorgida V, Venturini PL, Ferrero S. Endometriosis in menopause: a single institution experience. Arch Gynecol Obstet. 2012;286(6):1571-5.
DOI: 10.1007/s00404-012-2473-5
PMID: 22825693
13. Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014;7(3):349-57.
PMID: 25408753
14. Rolla E. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. F1000Res. 2019;8:F1000 Faculty Rev-529.
DOI: 10.12688/f1000research.14817.1
PMID: 31069056
15. Saccardi C, Cosmi E, Borghero A, Tregnaghi A, Dessole S, Litta P. Comparison between transvaginal sonography, saline contrast sonovaginography and magnetic resonance imaging in the diagnosis of posterior deep infiltrating endometriosis. Ultrasound Obstet Gynecol. 2012;40(4):464-9.
DOI: 10.1002/uog.11102
PMID: 22253192
16. Yin S, Lin Q, Xu F, Xu J, Zhang Y. Diagnosis of Deep Infiltrating Endometriosis Using Transvaginal Ultrasonography. Front Med (Lausanne). 2020;7:567929.
DOI: 10.3389/fmed.2020.567929
PMID: 33330527
17. Lorusso F, Scioscia M, Rubini D, Stabile Ianora AA, Scardigno D, Leuci C, et al. Magnetic resonance imaging for deep infiltrating endometriosis: current concepts, imaging technique and key findings. Insights Imaging. 2021;12(1):105.
DOI: 10.1186/s13244-021-01054-x
PMID: 34292422
18. Vimercati A, Achilarre MT, Scardapane A, Lorusso F, Ceci O, Mangiatordi G, et al. Accuracy of transvaginal sonography and contrast-enhanced magnetic resonance-colonography for the presurgical staging of deep infiltrating endometriosis. Ultrasound Obstet Gynecol. 2012;40(5):592-603.
DOI: 10.1002/uog.11179
PMID: 22535651
19. Alborzi S, Rasekhi A, Shomali Z, Madadi G, Alborzi M, Kazemi M, et al. Diagnostic accuracy of magnetic resonance imaging, transvaginal, and transrectal ultrasonography in deep infiltrating endometriosis. Medicine (Baltimore). 2018;97(8):e9536.
DOI: 10.1097/MD.0000000000009536
PMID: 29465552
20. Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. Curr Obstet Gynecol Rep. 2017;6(1):34-41.
DOI: 10.1007/s13669-017-0187-1
PMID: 29276652
21. Kobayashi H, Yamada Y, Kawahara N, Ogawa K, Yoshimoto C. Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis. Oncol Lett. 2019;17(1):1196-202.
PMID: 30655884
22. Habib N, Centini G, Lazzeri L, Amoruso N, El Khoury L, Zupi E, et al. Bowel Endometriosis: Current Perspectives on Diagnosis and Treatment. Int J Womens Health. 2020;12:35-47.
DOI: 10.2147/IJWH.S190326
PMID: 32099483
23. Karimi-Zarchi M, Dehshiri-Zadeh N, Sekhavat L, Nosouhi F. Correlation of CA-125 serum level and clinico-pathological characteristic of patients with endometriosis. Int J Reprod Biomed (Yazd). 2016;14(11):713-8.
DOI: 10.29252/ijrm.14.11.713
PMID: 28008424
24. O DF, Fassbender A, Van Bree R, Laenen A, Peterse DP, Vanhie A, et al. Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis. BioMed Res Int. 2019;2019:3673060.
DOI: 10.1155/2019/3673060
PMID: 31428634
25. Ozyurek ES, Yoldemir T, Kalkan U. Surgical challenges in the treatment of perimenopausal and postmenopausal endometriosis. Climacteric. 2018;21(4):385-90.
DOI: 10.1080/13697137.2018.1439913
PMID: 29493295
26. Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, et al.; ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2).
DOI: 10.1093/hropen/hoac009
PMID: 35350465
27. Somboonporn W, Panna S, Temtanakitpaisan T, Kaewrudee S, Soontrapa S. Effects of the levonorgestrel-releasing intrauterine system plus estrogen therapy in perimenopausal and postmenopausal women: systematic review and meta-analysis. Menopause. 2011;18(10):1060-6.
DOI: 10.1097/gme.0b013e31821606c5
PMID: 21720280
28. Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM. The management of menopause in women with a history of endometriosis: a systematic review. Hum Reprod Update. 2017;23(4):481-500.
DOI: 10.1093/humupd/dmx011
PMID: 28498913
29. Słopień R, Męczekalski B. Aromatase inhibitors in the treatment of endometriosis. Przegl Menopauz. 2016;15(1):43-7.
DOI: 10.5114/pm.2016.58773
PMID: 27095958
30. Cai X, Liu M, Zhang B, Zhao SJ, Jiang SW. Phytoestrogens for the Management of Endometriosis: findings and Issues. Pharmaceuticals (Basel). 2021;14(6):569.
DOI: 10.3390/ph14060569
PMID: 34198709
31. Al Kadri H, Hassan S, Al-Fozan HM, Hajeer A. Hormone therapy for endometriosis and surgical menopause. Cochrane Database Syst Rev. 2009(1).
DOI: 10.1002/14651858.CD005997.pub2
PMID: 19160262
32. Matorras R, Elorriaga MA, Pijoan JI, Ramón O, Rodríguez-Escudero FJ. Recurrence of endometriosis in women with bilateral adnexectomy (with or without total hysterectomy) who received hormone replacement therapy. Fertil Steril. 2002;77(2):303-8.
DOI: 10.1016/S0015-0282(01)02981-8
PMID: 11821087
33. Grisdale M, Alghamdi S, Boutross-Tadross O, Luketic L. Asymptomatic Atypical Hyperplasia and Endometriosis Following Treatment with Tamoxifen: A Case Report and Review of the Literature. J Obstet Gynaecol Can. 2021;43(1):85-7.
DOI: 10.1016/j.jogc.2020.04.018
PMID: 32739356
34. Bese T, Simsek Y, Bese N, Ilvan S, Arvas M. Extensive pelvic endometriosis with malignant change in tamoxifen-treated postmenopausal women. Int J Gynecol Cancer. 2003;13(3):376-80.
DOI: 10.1046/j.1525-1438.2003.13188.x
PMID: 12801273
35. Ye J, Peng H, Huang X, Qi X. The association between endometriosis and risk of endometrial cancer and breast cancer: a meta-analysis. BMC Womens Health. 2022;22(1):455.
DOI: 10.1186/s12905-022-02028-x
PMID: 36401252
36. Sorbi F, Capezzuoli T, Saso S, Fambrini M, Corda M, Fantappiè G, et al. The relation between endometrioma and ovarian cancer. Minerva Obstet Gynecol. 2021;73(3):347-53.
DOI: 10.23736/S2724-606X.21.04757-2
PMID: 34008389
37. Marie-ScemamaEven M, De La Joliniere JB, Ayoubi J-M. Endometriosis and the menopause: why the question merits our full attention. Horm Mol Biol Clin Investig. 2019;37(2).
DOI: 110.1515/hmbci-2018-0071
PMID: 30913034
38. Thomsen LH, Schnack TH, Buchardi K, Hummelshoj L, Missmer SA, Forman A, et al. Risk factors of epithelial ovarian carcinomas among women with endometriosis: a systematic review. Acta Obstet Gynecol Scand. 2017;96(6):761-78.
DOI: 10.1111/aogs.13010
PMID: 27565819
39. Shigesi N, Kvaskoff M, Kirtley S, Feng Q, Fang H, Knight JC, et al. The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(4):486-503.
DOI: 10.1093/humupd/dmz014
PMID: 31260048
40. Charatsi D, Koukoura O, Ntavela IG, Chintziou F, Gkorila G, Tsagkoulis M, et al. Gastrointestinal and Urinary Tract Endometriosis: A Review on the Commonest Locations of Extrapelvic Endometriosis. Adv Med. 2018;2018:3461209.
DOI: 10.1155/2018/3461209
PMID: 30363647
41. Snyder BM, Beets JW, Lessey BA, Horton SR, Abrams GA. Postmenopausal Deep Infiltrating Endometriosis of the Colon: Rare Location and Novel Medical Therapy. Case Rep Gastrointest Med. 2018;2018:9587536.
DOI: 10.1155/2018/9587536
PMID: 29666722
42. Milone M, Mollo A, Musella M, Maietta P, Sosa Fernandez LM, Shatalova O, et al. Role of colonoscopy in the diagnostic work-up of bowel endometriosis. World J Gastroenterol. 2015;21(16):4997-5001.
DOI: 10.3748/wjg.v21.i16.4997
PMID: 25945014
43. Ponticelli C, Graziani G, Montanari E. Ureteral endometriosis: a rare and underdiagnosed cause of kidney dysfunction. Nephron Clin Pract. 2010;114(2):c89-93.
DOI: 10.1159/000254380
PMID: 19887828
44. Stewart WW, Ireland GW. Vesical endometriosis in a postmenopausal woman: a case report. J Urol. 1977;118(3):480-1.
DOI: 10.1016/S0022-5347(17)58072-6
PMID: 904066
45. Yukumi S, Suzuki H, Morimoto M, Shigematsu H, Sugimoto R, Sakao N, et al. A case of thoracic endometriosis-related pneumothorax in a menopausal woman. Gen Thorac Cardiovasc Surg. 2020;68(12):1584-6.
DOI: 10.1007/s11748-020-01381-8
PMID: 32409913
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