Variability in pharmacological response to metformin treatment
Keywords:
pharmacogenetics, type 2 diabetes, polycystic ovary syndrome, genetic polymorphisms, pharmacotherapyAbstract
Background: According to the Slovenian guidelines, metformin, an oral antidiabetic drug, is a drug of choice for the treatment of type 2 diabetes. Additionally, metformin is paving its way in polycystic ovary syndrome (PCOS) treatment, although the drug has not (yet) been officially indicated to treat PCOS. Studies have shown that metformin improves clinical and biochemical features of PCOS as well as the rate of ovulation and consequently the likelihood of conception in PCOS women. At the same dosage regimen, pharmacological effects of metformin show interindividual variability in metformin response; efforts have been made to at least partly explain the variability with polymorphic variants in genes related to metformin pharmacodynamics and pharmacokinetics.
Conclusions: The results of the current studies indicate that polymorphic variants in genes related to metformin pharmacodynamics and pharmacokinetics may contribute to the interindividual variability in pharmacological response to metformin treatment in diabetic as well as in PCOS patients.
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