Patient Blood Management - modern approaches for optimization of blood transfusion

Authors

  • Primož Poženel Blood transfusion centre of Slovenia
  • Samo Zver Ljubljana University Medical Centre, Department of Hematology
  • Božidar Nikolić Maribor University Medical Centre, Transfusion centre
  • Primož Rožman Blood transfusion centre of Slovenia, Diagnostic services department

DOI:

https://doi.org/10.6016/ZdravVestn.1357

Keywords:

restrictive blood use, improved transfusion procedures, artificial blood replacements, clinical guidelines for blood use, Patient Blood Management

Abstract

As a precious biological substance, donated blood has to be used in a sustainable, safe and efficient manner. Therefore good transfusion practice in modern surgery, anaesthesiology and intensive care is of key importance.  New therapeutic methods, operations, transplantation of organs and hematopoietic stem cells often require intensive and long term supportive therapy including transfusions of blood components. Nowadays, transfusion service is confronted with continuously increasing demand for sufficient quantity of safe high quality blood, and on the other hand with limited resources of blood.  The article deals with the current modern approaches for optimization of transfusion practice and Patient Blood Management that have to be implemented  in Slovenian hospitals.

 

Downloads

Download data is not yet available.

Author Biographies

  • Primož Poženel, Blood transfusion centre of Slovenia
    Blood transfusion centre of Slovenia, Therapy services department, MD, specialist in transfusion medicine
  • Samo Zver, Ljubljana University Medical Centre, Department of Hematology
    Ljubljana University Medical Centre, Department of Hematology, MD, PhD, Professor at the Medical Faculty, University of Ljubljana, Chair for Internal Medicine
  • Božidar Nikolić, Maribor University Medical Centre, Transfusion centre
    Maribor University Medical Centre, Transfusion centre, MD, specialist in transfusion medicine
  • Primož Rožman, Blood transfusion centre of Slovenia, Diagnostic services department
    Blood transfusion centre of Slovenia, Diagnostic services department, MD, PhD, Professor at the Medical Faculty, University of Ljubljana, Chair for Internal Medicine (Transfusion medicine)

References

Heier HE, Bugge W, Hjelmeland K, Soreide E, Sorlie D, Haheim LL. Transfusion vs. alternative treatment modalities in acute bleeding: a systematic review. Acta Anaesthesiol Scand 2006; 50: 920–931

Council of Europe. The collection, testing and use of blood and blood products in Europe in 2003 www.coe.int/ [accessed on 25th May 2013].

Wallace EL, Churchill WH, Surgenor DM, Cho GS, McGurk S. Collection and transfusion of blood and blood components in the United States, 1994. Transfusion 1998; 38: 625–36.

Zdravstveni statistični letopisi 2002–2012, transfuzijska dejavnost, Inštitut za varovanje zdravja RS

Poročilo o transfuzijski dejavnosti za leto 2013, Zavod RS za transfuzijsko medicino

Poročilo o transfuzijski dejavnosti za leto 2014, Zavod RS za transfuzijsko medicino

Stanworth SJ, Cockburn HC, Boralessa H, Contreras M. Which groups of patients are transfused? A study of red cell usage in London and southeast England. Vox Sang 2002; 83: 352-7.

Cahill MR, Joyce S, O Brien N, Casey M. Haemovigilance is assocciated with decreased use and improved appropriatess of blood transfusion. Vox Sang 2003; 85: 121-2.

Klein HG, Spahn DR, Carson JL. Red blood cell transfusion in clinical practice. Lancet 2007; 370: 415–426.

Marik PE, Corwin HL. Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med. 2008; 36: 2667–2674.

Earley AS, Gracias VH, Haut E, Sicoutris CP, Wiebe DJ, Reilly PM et al. Anemia management program reduces transfusion volumes, incidence of ventilator-associated pneumonia, and cost in trauma patients. J Trauma 2006; 61: 1–5.

Kleinert K, Theusinger OM, Nuernberg J, Werner CM. Alternative Procedures for Reducing Allogeneic Blood Transfusion in Elective Orthopedic Surgery. HSS J. 2010; 6: 190-198.

Carless PA, Henry DA, Moxey AJ, O΄Connell DL, Brown T, Fergusson DA. Cell salvage for minimising perioperative allogeneic blood transfusion. Cochrane database of Systematic Reviews 2006, Issue 4. Art.No. CD001888.

Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G et al. A multicenter, randomised, controlled trial of transfusion requirements in critical care. New England Journal of Medicine 2004; 340: 409-17.

Henry DA, Moxley AJ, Carless PA, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Datebase of Sytematic Reviews 2007, Issue 4.Art.No. CD001886.

Murphy MF, Howell C. Survey of the implementation of recommendations in the Health Service Circular 2002/009 ‛Better Blood Transfusion’. Transfusion Medicine 2005; 15: 453-60.

Stansworth SJ, Birchall J, Doree CJ, Hyde C. Recombinant factor VIIa for the prevention and treatement of bleeding in patients without haemophilia. Cochrane Database Systematic Reviews 2007; 18(2): CD005011.

Zver S, Domanović D, Stecher A. Priporočila za uporabo in zdravljenje s svežo zmrznjeno plazmo. Zdrav Vestn 2012; 81: 7–15

Department of Health. Better Blood Transfusion: Safe and appropriate use of blood. HSC 2007/001, Department of Health, London 2007

National Safety and Quality Health Service Standards, Standard 7: Blood and blood products. Australian Commission on Safety and Quality in Health Care, September 2012, ISBN: 978-1-921983-04-7

Shander A , Van Aken H, Colomina MJ, Gombotz H, Hofmann A, Krauspe R et al.: Patient blood management in Europe. Br J Anaesth. 2012 Jul; 109(1): 55–68.

Goodnough LT, Maniatis A, Earnshaw P, Benoni G, Beris P, Bisbe E et al. Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines. Br J of Anaesth 2011; 106: 13-22.

Cuenca J, Garcia-Erce JA, Martinez F, Perez-Serrano L, Herrera A, Munoz M. Perioperative intravenous iron, with or without erythropoietin, plus restrictive transfusion protocol reduce the need for allogeneic blood after knee replacement surgery. Transfusion 2006; 46: 1112–1119.

Erslev AJ. Review Erythropoietin. N Engl J Med 1991; 324: 1339-44.

Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J et al. Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomized trials. Lancet 2009; 373: 1532-42

Chassot PG, Delabays A, Spahn DR. Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction. Br J Anaesth 2007; 99: 316–328.

Bryson GL, Laupacis A, Wells GA. Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion? A meta-analysis. The International Study of Perioperative Transfusion. Anesth Analg 1998; 86: 9–15.

Segal JB, Blasco-Colmenares E, Norris EJ, Guallar E. Preoperative acute normovolemic hemodilution: a meta-analysis. Transfusion 2004; 44: 632–644.

Larkin M. Value of preoperative autologous blood donation questioned. Lancet. 2002; 360: 696.

Henry DA, Carless PA, Moxey AJ, O'Connell D, Forgie MA, Wells PS et al. Pre-operative autologous donation for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2002; (2): CD003602.

Schmied H, Kurz A, Sessler DI, Kozek S, Reiter A. Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty. Lancet. 1996;347(8997):289–292.

Winkler M, Akc O, Birkenberg B, Hetz H, Scheck T, Arkilic CF. Aggressive warming reduces blood loss during hip arthroplasty. Anesth Analg 2000; 91: 978–984.

Anderson L, Quasim I, Soutar R, Steven M, Macfie A, Korte W. An audit of red cell and blood product use after the institution of thromboelastometry in a cardiac intensive care unit. Transfus Med 2006; 16: 31–39.

Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg 2008; 106: 1366–1375

Lang T, Bauters A, Braun SL, Potzsch B, von Pape KW, Kolde HJ et al. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis 2005, 16: 301-310.

Niemi TT, Pitkanen M, Syrjala M, Rosenberg PH. Comparison of hypotensive epidural anaesthesia and spinal anaesthesia on blood loss and coagulation during and after total hip arthroplasty. Acta Anaesthesiol Scand 2000; 44: 457–464.

Andersson I, Tylman M, Bengtson JP, Bengtsson A. Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty. Can J Anaesth 2001; 48: 251–255.

Esper SA, Waters JH. Intra-operative cell salvage: a fresh look at the indications and contraindications. Blood Transfus 2011; 9: 139–147.

Dai B, Wang L, Djaiani G, Mazer CD. Continuous and discontinuous cell-washing autotransfusion systems. J Cardiothorac Vasc Anesth 2004;18: 210–217.

Heddle NM, Brox WT, Klama LN, Dickson LL, Levine MN. A randomized trial on the efficacy of an autologous blood drainage and transfusion device in patients undergoing elective knee arthroplasty. Transfusion 1992; 32: 742–746.

Beck-Schimmer B, Romero B, Booy C, Joch H, Hallers U, Pasch T et al. Release of inflammatory mediators in irradiated cell salvage blood and their biological consequences in human beings following transfusion. Eur J Anaesthesiol 2004; 21: 46–52.

Paterson JM, Mamdani M, Juurlink DN, Naglie G,Laupacis A, Stukel TA. Clinical

consequences of generic warfarin substitution: an ecological study. JAMA

; 296: 1969-1972.

Dezee KJ, Shimeall WT, Douglas KM, Shumway NM, O'Malley PG . Treatment of

excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch Intern Med 2006; 166: 391–397.

Douketis JD, Berger PB, Dunn AS, Jaffer AK, Spyropoulos AC, Becker RC et al. The perioperative management of antithrombotic therapy: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2008; 133: 299–339.

Holbrook A, Schulman S, Witt DM, Vandvik PO, Fish J, Kovacs MJ et al. Evidence-based management of anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest 2012; 141(2 Suppl): e152S-84S.

Weinkove R, Rangarajan S. Fibrinogen concentrate for acquired hypofibrinogenaemic states. S Transfus Med 2008; 18: 151-7.

Barer D, Ogilvie A, Henry D, Dronfield M, Coggon D, French S et al. Cimetidine and tranexamic acid in thetreatment of acute upper-gastrointestinal-tract bleeding. N Engl J Med 1983; 308: 1571–5.

Dunn CJ, Goa KL. Tranexamic acid: a review of its use insurgery and other indications. Drugs 1999; 57: 1005–32.

CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with signifi cant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010; 376(9734): 23-32.

Mangano DT, Tudor IC, Dietzel C; Multicenter Study of Perioperative Ischemia Research Group; Ischemia Research and Education Foundation. Ther risk associated with aprotinin in cardiac surgery, New England Jurnal of Medicine 2006; 354: 353-65.

Fergusson DA, Hebert PC, Mazer CD, Fremes S, MacAdams C, Murkin JM et al. A

comparison of Aprotinin and Lysine Analogues in High-Risk Cardiac Surgery, New England Jurnal of Medicine 2008; 358: 2319-31

Everts PA, Devilee RJ, Brown Mahoney C, Eeftinck-Schattenkerk M, Box HA, Knape JT et al. Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty. Acta Anaesthesiol Scand 2006; 50: 593–599.

Rožman P, Bolta Z. Use of platelet growth factors in treating wounds and soft-tissue injuries. Acta Dermatovenerol Alp Panonica Adriat 2007; 16: 156-65.

Mankad PS, Codispoti M. The role of fibrin sealants in hemostasis. Am J Surg 2001;182(2 Suppl): 21S–28S.

Levy O, Martinowitz U, Oran A, Tauber C, Horoszowski H. The use of fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty. A prospective, randomized, multicenter study. J Bone Joint Surg Am 1999; 81: 1580–1588.

Wang GJ, Hungerford DS, Savory CG, Rosenberg AG, Mont MA, Burks SG et al. Use of fibrin sealant to reduce bloody drainage and hemoglobin loss after total knee arthroplasty: a brief note on a randomized prospective trial. J Bone Joint Surg Am 2001; 83: 1503–1505.

Dutton RP, McCunn M, Hyder M, D'Angelo M, O'Connor J, Hess JR et al. Factor VIIa for correction of traumatic coagulopathy. J Trauma 2004; 57: 709–718

Friederich PW, Henny CP, Messelink EJ, Geerdink MG,Keller T, Kurth K-H et al. Effect of recombinant activated factor VII on perioperative blood loss in patients undergoingretropubic prostatectomy: a double-blind placebo-controlledrandomised trial. Lancet 2003; 361: 201–5

Winslow RM. Current status of oxygen carriers (“blood substitutes”): 2006. Vox Sang 2006; 91: 102-10.

Harrington JP, Wollocko H. Pre-clinical studies using OxyVita hemoglobin, a zero-linked polymeric hemoglobin: a review. J Artif Organs 2010; 13: 183-8.

Kaneda S, Ishizuka T, Goto H, Kimura T, Inaba K, Kasukawa H. Liposome-encapsulated Hemoglobin, TRM-645: Current Status of the Development and Important Issues for Clinical Application. Artif Organs 200 ; 33: 146-52.

Dong F, Hall CH, Golech SA, Philbin NB, Rice JP, Gurney J et al. Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage. Shock 2006; 25: 50-5

Gould SA, Rosen AL, Sehgal LR, Sehgal HR, Langdale LA,Krause LM et al. Fluosol-DA as a red-cell substitute in acuteanemia. N Engl J Med 1986; 314: 1653–6.

Spahn DR, Waschke KF, Standl T, Motsch J, Van HuynegemL, Welte M et al. Use of perflubron emulsion to decrease allogeneic blood transfusion in high-blood-loss non-cardiac surgery: results of a European phase 3 study. Anesthesiology 2002; 97: 1338-49.

Price CD, El-Badri NS, Haas DKA, Chaparro RE, Mangar D, Camporesi EM. The evaluation of the efficacy of Oxygent® as an oxygen-carrying substitute on cerebral blood flow. The open Hematology Journal 2008; 2: 62-66

Maevsky E, Ivanitsky G, Bogdanova L, Axenova O, Karmen N, Zhiburt E et al. Clinical results of Perftoran application: present and future. Artif Cells Blood Substit Immobil Biotechnol 2005; 33: 37-46.

Verdin-Vasquez RC, Zepeda-Perez C, Ferra-Ferrer R, Chavez-Negrete A, Contreras F, Barroso-Aranda J. Use of perftoran emulsion to decrease allogeneic blood transfusion in cardiac surgery: clinical trial. Artif Cells Blood Substit Immobil Biotechnol 2006; 34: 433-54.

Sarode R, Refaai MA, Matevosyan K, Burner JD, Hampton S, Rutherford C. Prospective monitoring of plasma and platelet transfusions in a large teaching hospital results in significant cost reduction. Transfusion 2010; 50: 487-92.

Na HS, Shin SY, Hwang JY, Jeon YT, Kim CS, Do SH. Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty. Transfusion 2011; 51: 118-24.

Tavares M, DiQuattro P, Nolette N, Conti G, Sweeney J. Reduction in plasma transfusion after enforcement of transfusion guidelines. Transfusion 2011; 51: 754-61.

Hannon T. Transfusion guidelines: Development and impact on blood management. In: Saxena S, Shulman IA, eds. The transfusion committee: Putting patient safety first. Bethesda, MD: AABB Press, 2006: 115-29.

Phillips SD, Maguire D, Deshpande R, Muiesan P, Bowles MJ, Rela M et al. A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation. Transplantation 2006; 81: 536-40.

Waters JR, Meier HH, Waters JH. An economic analysis of costs associated with development of a cell salvage program. Anesth Analg 2007; 104: 869-75.

Published

2015-12-14

How to Cite

1.
Patient Blood Management - modern approaches for optimization of blood transfusion. ZdravVestn [Internet]. 2015 Dec. 14 [cited 2024 Nov. 2];84(11). Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/1357

Most read articles by the same author(s)

1 2 3 4 5 6 > >>