Metastatic disease of the spine
DOI:
https://doi.org/10.6016/ZdravVestn.3141Keywords:
cancer, spine, metastasis, surgery, oncology, radiotherapy, spinal instability, spinal cord compressionAbstract
Tumours of the spine are either primary or secondary. The spine is the most common site where we find bone metastases. Up to 70% of patients with cancer develop a metastasis in the spine. Up to 10% of patients with cancer suffer from metastatic spinal cord compression. Metastases in the spine are 20 times more common then primary tumours. Very often they are the first sign of a systemic cancer disease that we find. The symptoms of metastatic spine disease are very varied. There are many different approaches to treatment, and there has been tremendous advancement in recent years, especially with the development of stereotactic radiotherapy. The tretment of metastatic spine disease is a very complex and important field of medicine. It takes an interdisciplinary and decisive approach to save the patient’s critical spinal function. Not recognizing metastatic spinal disease or its inappropriate treatment usually has irreversible consequences.
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References
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<p>2. Yurter AJ, Sciubba DM. Management of Metastatic Spine Disease. JSM Neurosurg Spine. 2014;2(2):1020.</p>
<p>3. Choi D, Crockard A, Bunger C, Harms J, Kawahara N, Mazel C, et al.; Global Spine Tumor Study Group. Review of metastatic spine tumour classification and indications for surgery: the consensus statement of the Global Spine Tumour Study Group. Eur Spine J. 2010;19(2):215-22. <br />DOI: <a href="https://doi.org/10.1007/s00586-009-1252-x">10.1007/s00586-009-1252-x</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/20039084">20039084</a></p>
<p>4. Klimo P, Schmidt MH. Surgical management of spinal metastases. Oncologist. 2004;9(2):188-96. <br />DOI: <a href="https://doi.org/10.1634/theoncologist.9-2-188">10.1634/theoncologist.9-2-188</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/15047923">15047923</a></p>
<p>5. Guzik G. Current Incidence of Different Morphological Types of Malignant Metastases to the Spine Based on Magnetic Resonance Imaging. Ortop Traumatol Rehabil. 2017;19(2):137-44. <br />DOI: <a href="https://doi.org/10.5604/15093492.1238001">10.5604/15093492.1238001</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/28508764">28508764</a></p>
<p>6. Perrin RG, Laxton AW. Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients. Neurosurg Clin N Am. 2004;15(4):365-73. <br />DOI: <a href="https://doi.org/10.1016/j.nec.2004.04.018">10.1016/j.nec.2004.04.018</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/15450871">15450871</a></p>
<p>7. Fridley JS, Hepel JT, Oyelese AA. Current Treatment of Metastatic Spine Tumors - Surgery and Stereotactic Radiosurgery. R I Med J (2013). 2017;100(6):18-20. <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/28564663">28564663</a></p>
<p>8. Galgano M, Fridley J, Oyelese A, Telfian A, Kosztowski T, Choi D, et al. Surgical management of spinal metastases. Expert Rev Anticancer Ther. 2018;18(5):463-72. <br />DOI: <a href="https://doi.org/10.1080/14737140.2018.1453359">10.1080/14737140.2018.1453359</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29560739">29560739</a></p>
<p>9. L’espérance S, Vincent F, Gaudreault M, Ouellet JA, Li M, Tosikyan A, et al.; Comité de l’évolution des pratiques en oncologie. Treatment of metastatic spinal cord compression: cepo review and clinical recommendations. Curr Oncol. 2012;19(6):e478-90. <br />DOI: <a href="https://doi.org/10.3747/co.19.1128">10.3747/co.19.1128</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/23300371">23300371</a></p>
<p>10. Maccauro G, Spinelli MS, Mauro S, Perisano C, Graci C, Rosa MA. Physiopathology of spine metastasis. Int J Surg Oncol. 2011;2011:107969. <br />DOI: <a href="https://doi.org/10.1155/2011/107969">10.1155/2011/107969</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/22312491">22312491</a></p>
<p>11. Algra PR, Heimans JJ, Valk J, Nauta JJ, Lachniet M, Van Kooten B. Do metastases in vertebrae begin in the body or the pedicles? Imaging study in 45 patients. AJR Am J Roentgenol. 1992;158(6):1275-9. <br />DOI: <a href="https://doi.org/10.2214/ajr.158.6.1590123">10.2214/ajr.158.6.1590123</a> <br />PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/1590123">1590123</a></p>
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Metastatic disease of the spine. ZdravVestn [Internet]. 2022 Apr. 30 [cited 2024 Nov. 2];91(3-4):117-2. Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/3141
