Metastatic tumours to hypophysis: a report of three cases and review of literature

  • Tomaž Šmigoc Oddelek za nevrokirurgijo, UKC Maribor
  • Tomaž Velnar Oddelek za nevrokirurgijo, UKC Maribor
  • Urša Kšela Oddelek za endokrinologijo in diabetologijo, UKC Maribor
  • Maja Ravnik Oddelek za ginekološko onkologijo in onkologijo dojk, UKC Maribor
  • Boštjan Lanišnik Oddelek za otorinolaringologijo, UKC Maribor
  • Gorazd Bunc Oddelek za nevrokirurgijo, UKC Maribor
  • Janez Ravnik 1Oddelek za nevrokirurgijo, UKC Maribor
Keywords: metastases, pituitary tumours, surgery, lymphoma, breast cancer, renal cell carcinoma

Abstract

Background. Metastatic tumours to pituitary are rare. The most frequent are metastases from breast and lung.

Methods. In this paper, three cases of metastatic tumours to the pituitary are presented with panhypopituitarism as a common symptom: I) a 60-year-old gentleman with metastasis of diffuse large B cell lymphoma, who presented with diabetes insipidus, II) a 54-year-old lady with metastatic renal clear cell carcinoma and consequent disturbances in visual acuity, brain nerve paresis and III) a 57-year-old lady with breast cancer metastasis, visual impairment and brain nerve paresis.

Results. A transnasal endoscopic resection of the tumours was performed in all cases, followed by oncological treatment. All patients improved after the treatment.

Conclusions. Despite the rarity of the disease, a metastatic tumour to the pituitary gland must be included in the differential diagnosis when symptoms such as diabetes insipidus, ophthalmoplegy due to brain nerve palsies, rapid course of the disease and headache are observed. In 20% to 30%, pituitary metastases are the first manifestation of a tumour of unknown origin. Surgical and adjuvant therapy may improve the quality of life. The survival and prognosis are generally poor.

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Author Biographies

Tomaž Šmigoc, Oddelek za nevrokirurgijo, UKC Maribor
Oddelek za nevrokirurgijo, UKC Maribor
Tomaž Velnar, Oddelek za nevrokirurgijo, UKC Maribor
Oddelek za nevrokirurgijo, UKC Maribor
Urša Kšela, Oddelek za endokrinologijo in diabetologijo, UKC Maribor
Oddelek za endokrinologijo in diabetologijo, UKC Maribor
Maja Ravnik, Oddelek za ginekološko onkologijo in onkologijo dojk, UKC Maribor
Oddelek za ginekološko onkologijo in onkologijo dojk, UKC Maribor
Boštjan Lanišnik, Oddelek za otorinolaringologijo, UKC Maribor
Oddelek za otorinolaringologijo, UKC Maribor
Gorazd Bunc, Oddelek za nevrokirurgijo, UKC Maribor
Oddelek za nevrokirurgijo, UKC Maribor
Janez Ravnik, 1Oddelek za nevrokirurgijo, UKC Maribor
Oddelek za nevrokirurgijo, UKC Maribor

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Published
2016-08-29
How to Cite
1.
Šmigoc T, Velnar T, Kšela U, Ravnik M, Lanišnik B, Bunc G, Ravnik J. Metastatic tumours to hypophysis: a report of three cases and review of literature. ZdravVestn [Internet]. 29Aug.2016 [cited 15Nov.2019];85(7-8). Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/1385
Section
Case report, short scientific article