Assessment of analgesia, sedation, delirium and sleep disturbance in the intensive care therapy unit and description of non-pharmacological interventions

Authors

  • Andreja Möller Petrun Department of Anaesthesiology, Intensive Therapy and Pain Therapy, University Medical Centre Maribor, Maribor, Slovenia

DOI:

https://doi.org/10.6016/ZdravVestn.3055

Keywords:

pain measurement, confussion, fear, sleeplessness, intensive therapy

Abstract

Treatment in the intensive therapy unit is very stressful for most patients. It has an important impact on their quality of life and can have long-term consequences. Among others, there are serious complaints such as pain, fear, sleeplessness, thirst, helplessness, fatigue, confusion and agitation. These all can exert adverse impact on the therapy process and clinical outcome. Patients often develop delirium, which is not only a great burden for the patient but also for the personnel caring for the patient. Delirium also has a long-term negative impact on the patient’s cognitive functions. Medical staff has a great responsibility for detecting and dealing with these problems, especially in patients with limited cognitive functions or impaired communication ability. There are different tools for the assessment of pain, sedation, delirium and sleep quality. In this article, we describe the most frequently used validated scoring systems for the assessment of pain, sedation, delirium and sleep disturbance. Furthermore, the non-pharmacological approach is described.

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References

1. Puntillo KA, Arai S, Cohen NH, Gropper MA, Neuhaus J, Paul SM, et al. Symptoms experienced by intensive care unit patients at high risk of dying. Crit Care Med. 2010;38(11):2155-60.
DOI: 10.1097/CCM.0b013e3181f267ee
PMID: 20711069

2. Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, et al.; BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306-16.
DOI: 10.1056/NEJMoa1301372
PMID: 24088092

3. Sricharoenchai T, Parker AM, Zanni JM, Nelliot A, Dinglas VD, Needham DM. Safety of physical therapy interventions in critically ill patients: a single-center prospective evaluation of 1110 intensive care unit admissions. J Crit Care. 2014;29(3):395-400.
DOI: 10.1016/j.jcrc.2013.12.012
PMID: 24508202

4. Nelson BJ, Weinert CR, Bury CL, Marinelli WA, Gross CR. Intensive care unit drug use and subsequent quality of life in acute lung injury patients. Crit Care Med. 2000;28(11):3626-30.
DOI: 10.1097/00003246-200011000-00013
PMID: 11098964

5. Wade D, Hardy R, Howell D, Mythen M. Identifying clinical and acute psychological risk factors for PTSD after critical care: a systematic review. Minerva Anestesiol. 2013;79(8):944-63.
PMID: 23558761

6. Bürkle H, Eggers V, Horter J, Kessler P, Kleinschmidt S, Meiser A, et al. Analgesie, Sedierung und Delirmanagement in der Intensivmedizin (DAS-Leitlinie 2015). Nürnberg: Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin; 2015 [cited 2020 Mar 20]. Available from: https://www.awmf.org/uploads/tx_szleitlinien/001-012p_S3_Analgesie_Sedierung_Delirmanagement_Intensivmedizin_2015-08-abgelaufen.pdf.

7. Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJ, Pandharipande PP, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med. 2018;46(9):e825-73.
DOI: 10.1097/CCM.0000000000003299
PMID: 30113379

8. Jakob SM, Lubszky S, Friolet R, Rothen HU, Kolarova A, Takala J. Sedation and weaning from mechanical ventilation: effects of process optimization outside a clinical trial. J Crit Care. 2007;22(3):219-28.
DOI: 10.1016/j.jcrc.2007.01.001
PMID: 17869972

9. Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008;371(9607):126-34.
DOI: 10.1016/S0140-6736(08)60105-1
PMID: 18191684

10. Whipple JK, Lewis KS, Quebbeman EJ, Wolff M, Gottlieb MS, Medicus-Bringa M, et al. Analysis of pain management in critically ill patients. Pharmacotherapy. 1995;15(5):592-9.
DOI: 10.1002/j.1875-9114.1995.tb02868.x
PMID: 8570431

11. Loeser JD, Treede RD. The Kyoto protocol of IASP basic pain terminology. Pain. 2008;137(3):473-7.
DOI: 10.1016/j.pain.2008.04.025
PMID: 18583048

12. Al Sutari MM, Abdalrahim MS, Hamdan-Mansour AM, Ayasrah SM. Pain among mechanically ventilated patients in critical care units. J Res Med Sci. 2014;19(8):726-32.
PMID: 25422657

13. de Jong A, Molinari N, de Lattre S, Gniadek C, Carr J, Conseil M, et al. Decreasing severe pain and serious adverse events while moving intensive care unit patients: a prospective interventional study (the NURSE-DO project). Crit Care. 2013;17(2):R74.
DOI: 10.1186/cc12683
PMID: 23597243

14. Chanques G, Viel E, Constantin JM, Jung B, de Lattre S, Carr J, et al. The measurement of pain in intensive care unit: comparison of 5 self-report intensity scales. Pain. 2010;151(3):711-21.
DOI: 10.1016/j.pain.2010.08.039
PMID: 20843604

15. Twining J, Padula C. The measurement of pain in intensive care unit: comparison of 5 self-report intensity scales. Pain Manag Nurs. 2019;20(5):462-7.
DOI: 10.1016/j.pmn.2019.02.005
PMID: 31103512

16. Gordon DB. Acute pain assessment tools: let us move beyond simple pain ratings. Curr Opin Anaesthesiol. 2015;28(5):565-9.
DOI: 10.1097/ACO.0000000000000225
PMID: 26237235

17. McGuire DB, Kaiser KS, Haisfield-Wolfe ME, Iyamu F. Pain assessment in non-communicative adult palliative care patients. Nurs Clin North Am. 2016;51(3):397-431.
DOI: 10.1016/j.cnur.2016.05.009
PMID: 27497016

18. Osterbrink J. Pain management in nursing care—experts standard. MMW Fortschr Med. 2005;147(15):34.
PMID: 15884501

19. Payen JF, Bru O, Bosson JL, Lagrasta A, Novel E, Deschaux I, et al. Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med. 2001;29(12):2258-63.
DOI: 10.1097/00003246-200112000-00004
PMID: 11801819

20. Gélinas C, Klein K, Naidech AM, Skrobik Y. Pain, sedation, and delirium management in the neurocritically ill: lessons learned from recent research. Semin Respir Crit Care Med. 2013;34(2):236-43.
DOI: 10.1055/s-0033-1342986
PMID: 23716314

21. Rijkenberg S, Stilma W, Endeman H, Bosman RJ, Oudemans-van Straaten HM. Pain measurement in mechanically ventilated critically ill patients: Behavioral Pain Scale versus Critical-Care Pain Observation Tool. J Crit Care. 2015;30(1):167-72.
DOI: 10.1016/j.jcrc.2014.09.007
PMID: 25446372

22. Rahu MA, Grap MJ, Ferguson P, Joseph P, Sherman S, Elswick RK. Validity and sensitivity of 6 pain scales in critically ill, intubated adults. Am J Crit Care. 2015;24(6):514-23.
DOI: 10.4037/ajcc2015832
PMID: 26523009

23. Severgnini P, Pelosi P, Contino E, Serafinelli E, Novario R, Chiaranda M. Accuracy of Critical Care Pain Observation Tool and Behavioral Pain Scale to assess pain in critically ill conscious and unconscious patients: prospective, observational study. J Intensive Care. 2016;4(1):68.
DOI: 10.1186/s40560-016-0192-x
PMID: 27833752

24. Dehghani H, Tavangar H, Ghandehari A. Validity and reliability of behavioral pain scale in patients with low level of consciousness due to head trauma hospitalized in intensive care unit. Arch Trauma Res. 2014;3(1):e18608.
DOI: 10.5812/atr.18608
PMID: 25032173

25. Paulus J, Roquilly A, Beloeil H, Théraud J, Asehnoune K, Lejus C. Pupillary reflex measurement predicts insufficient analgesia before endotracheal suctioning in critically ill patients. Crit Care. 2013;17(4):R161.
DOI: 10.1186/cc12840
PMID: 23883683

26. Gélinas C, Fillion L, Puntillo KA, Viens C, Fortier M. Validation of the critical-care pain observation tool in adult patients. Am J Crit Care. 2006;15(4):420-7.
DOI: 10.4037/ajcc2006.15.4.420
PMID: 16823021

27. Aïssaoui Y, Zeggwagh AA, Zekraoui A, Abidi K, Abouqal R. Validation of a behavioral pain scale in critically ill, sedated, and mechanically ventilated patients. Anesth Analg. 2005;101(5):1470-6.
DOI: 10.1213/01.ANE.0000182331.68722.FF
PMID: 16244013

28. Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104(1):21-6.
DOI: 10.1097/00000542-200601000-00005
PMID: 16394685

29. Shehabi Y, Bellomo R, Kadiman S, Ti LK, Howe B, Reade MC, et al.; Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: A multinational prospective longitudinal cohort study. Crit Care Med. 2018;46(6):850-9.
DOI: 10.1097/CCM.0000000000003071
PMID: 29498938

30. Burry L, Rose L, McCullagh IJ, Fergusson DA, Ferguson ND, Mehta S. Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation. Cochrane Database Syst Rev. 2014;7(7):CD009176.
DOI: 10.1002/14651858.CD009176.pub2
PMID: 25005604

31. Mehta S, Burry L, Cook D, et al. SLEAP Investigators; Canadian Critical Care Trials Group: Daily sedation interruption in mechani- cally ventilated critically ill patients cared for with a sedation protocol: A randomized controlled trial. JAMA. 2012;308:1985-92.
DOI: 10.1001/jama.2012.13872
PMID: 23180503

32. Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA. 2003;289(22):2983-91.
DOI: 10.1001/jama.289.22.2983
PMID: 12799407

33. Sessler CN, Grap MJ, Brophy GM. Multidisciplinary management of sedation and analgesia in critical care. Semin Respir Crit Care Med. 2001;22(2):211-26.
DOI: 10.1055/s-2001-13834
PMID: 16088675

34. Vivien B, Di Maria S, Ouattara A, Langeron O, Coriat P, Riou B. Overestimation of Bispectral Index in sedated intensive care unit patients revealed by administration of muscle relaxant. Anesthesiology. 2003;99(1):9-17.
DOI: 10.1097/00000542-200307000-00006
PMID: 12826836

35. Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62(10):1743-8.
DOI: 10.1212/01.WNL.0000125184.88797.62
PMID: 15159471

36. American Psychiatric AssociationDiagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, D.C.: APA; c2013.

37. Lipowski ZJ. Update on delirium. Psychiatr Clin North Am. 1992;15(2):335-46.
DOI: 10.1016/S0193-953X(18)30240-5
PMID: 1603727

38. Korošec Jagodič H, Jagodič K, Pregelj P. Obravnava bolnika z delirijem. Zdrav Vestn. 2009;78:473-80.

39. Ahmed S, Leurent B, Sampson EL. Risk factors for incident delirium among older people in acute hospital medical units: a systematic review and meta-analysis. Age Ageing. 2014;43(3):326-33.
DOI: 10.1093/ageing/afu022
PMID: 24610863

40. Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK. Characteristics associated with delirium in older patients in a medical intensive care unit. Arch Intern Med. 2007;167(15):1629-34.
DOI: 10.1001/archinte.167.15.1629
PMID: 17698685

41. Van Rompaey B, Elseviers MM, Schuurmans MJ, Shortridge-Baggett LM, Truijen S, Bossaert L. Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care. 2009;13(3):R77.
DOI: 10.1186/cc7892
PMID: 19457226

42. Hirsch J, DePalma G, Tsai TT, Sands LP, Leung JM. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Br J Anaesth. 2015;115(3):418-26.
DOI: 10.1093/bja/aeu458
PMID: 25616677

43. van den Boogaard M, Schoonhoven L, Maseda E, Plowright C, Jones C, Luetz A, et al. Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study. Intensive Care Med. 2014;40(3):361-9.
DOI: 10.1007/s00134-013-3202-7
PMID: 24441670

44. Pandharipande P, Cotton BA, Shintani A, Thompson J, Pun BT, Morris JA, et al. Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma. 2008;65(1):34-41.
DOI: 10.1097/TA.0b013e31814b2c4d
PMID: 18580517

45. Zhang WY, Wu WL, Gu JJ, Sun Y, Ye XF, Qiu WJ, et al. Risk factors for postoperative delirium in patients after coronary artery bypass grafting: A prospective cohort study. J Crit Care. 2015;30(3):606-12.
DOI: 10.1016/j.jcrc.2015.02.003
PMID: 25708120

46. Slooter AJ, Van De Leur RR, Zaal IJ. Delirium in critically ill patients. Handb Clin Neurol. 2017;141:449-66.
DOI: 10.1016/B978-0-444-63599-0.00025-9
PMID: 28190430

47. Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, et al. Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med. 2007;35(1):112-7.
DOI: 10.1097/01.CCM.0000251925.18961.CA
PMID: 17133176

48. Skrobik Y, Ahern S, Leblanc M, Marquis F, Awissi DK, Kavanagh BP. Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates. Anesth Analg. 2010;111(2):451-63.
DOI: 10.1213/ANE.0b013e3181d7e1b8
PMID: 20375300

49. Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291(14):1753-62.
DOI: 10.1001/jama.291.14.1753
PMID: 15082703

50. Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med. 2010;38(7):1513-20.
DOI: 10.1097/CCM.0b013e3181e47be1
PMID: 20473145

51. Shehabi Y, Riker RR, Bokesch PM, Wisemandle W, Shintani A, Ely EW; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group. Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med. 2010;38(12):2311-8.
DOI: 10.1097/CCM.0b013e3181f85759
PMID: 20838332

52. Inouye SK, Bogardus ST, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med. 1999;340(9):669-76.
DOI: 10.1056/NEJM199903043400901
PMID: 10053175

53. Schiemann A, Hadzidiakos D, Spies C. Managing ICU delirium. Curr Opin Crit Care. 2011;17(2):131-40.
DOI: 10.1097/MCC.0b013e32834400b5
PMID: 21301333

54. González-López A, Albaiceta GM, Talbot K. Newly identified precipitating factors in mechanical ventilation-induced brain damage: implications for treating ICU delirium. Expert Rev Neurother. 2014;14(6):583-8.
DOI: 10.1586/14737175.2014.915743
PMID: 24852225

55. Bilotta F, Lauretta MP, Borozdina A, Mizikov VM, Rosa G. Postoperative delirium: risk factors, diagnosis and perioperative care. Minerva Anestesiol. 2013;79(9):1066-76.
PMID: 23511351

56. van Gool WA, van de Beek D, Eikelenboom P. Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet. 2010;375(9716):773-5.
DOI: 10.1016/S0140-6736(09)61158-2
PMID: 20189029

57. Hopkins RO, Suchyta MR, Snow GL, Jephson A, Weaver LK, Orme JF. Blood glucose dysregulation and cognitive outcome in ARDS survivors. Brain Inj. 2010;24(12):1478-84.
DOI: 10.3109/02699052.2010.506861
PMID: 20858026

58. Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med. 2001;27(5):859-64.
DOI: 10.1007/s001340100909
PMID: 11430542

59. Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001;29(7):1370-9.
DOI: 10.1097/00003246-200107000-00012
PMID: 11445689

60. Gélinas C, Bérubé M, Chevrier A, Pun BT, Ely EW, Skrobik Y, et al. Delirium assessment tools in adult critically ill: A psychometric analysis and systematic review. Crit Care Nurse. 2018;38(1):38-49.
DOI: 10.4037/ccn2018633
PMID: 29437077

61. Egeland M, Zunszain PA, Pariante CM. Molecular mechanisms in the regulation of adult neurogenesis during stress. Nat Rev Neurosci. 2015;16(4):189-200.
DOI: 10.1038/nrn3855
PMID: 25790864

62. Tipping CJ, Young PJ, Romero L, Saxena MK, Dulhunty J, Hodgson CL. A systematic review of measurements of physical function in critically ill adults. Crit Care Resusc. 2012;14(4):302-11.
PMID: 23230880

63. Perpiñá-Galvañ J, Richart-Martínez M. Scales for evaluating self-perceived anxiety levels in patients admitted to intensive care units: a review. Am J Crit Care. 2009;18(6):571-80.
DOI: 10.4037/ajcc2009682
PMID: 19880959

64. Treggiari MM, Romand JA, Yanez ND, Deem SA, Goldberg J, Hudson L, et al. Randomized trial of light versus deep sedation on mental health after critical illness. Crit Care Med. 2009;37(9):2527-34.
DOI: 10.1097/CCM.0b013e3181a5689f
PMID: 19602975

65. Gabor JY, Cooper AB, Crombach SA, Lee B, Kadikar N, Bettger HE, et al. Contribution of the intensive care unit environment to sleep disruption in mechanically ventilated patients and healthy subjects. Am J Respir Crit Care Med. 2003;167(5):708-15.
DOI: 10.1164/rccm.2201090
PMID: 12598213

66. Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ. Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J Respir Crit Care Med. 2001;163(2):451-7.
DOI: 10.1164/ajrccm.163.2.9912128
PMID: 11179121

67. Elliott R, Rai T, McKinley S. Factors affecting sleep in the critically ill: an observational study. J Crit Care. 2014;29(5):859-63.
DOI: 10.1016/j.jcrc.2014.05.015
PMID: 24973105

68. Trompeo AC, Vidi Y, Locane MD, Braghiroli A, Mascia L, Bosma K, et al. Sleep disturbances in the critically ill patients: role of delirium and sedative agents. Minerva Anestesiol. 2011;77(6):604-12.
PMID: 21617624

69. Richards KC, O’Sullivan PS, Phillips RL. Measurement of sleep in critically ill patients. J Nurs Meas. 2000;8(2):131-44.
DOI: 10.1891/1061-3749.8.2.131
PMID: 11227580

70. Rivosecchi RM, Kane-Gill SL, Svec S, Campbell S, Smithburger PL. The implementation of a nonpharmacologic protocol to prevent intensive care delirium. J Crit Care. 2016;31(1):206-11.
DOI: 10.1016/j.jcrc.2015.09.031
PMID: 26596509

71. Colombo R, Corona A, Praga F, Minari C, Giannotti C, Castelli A, et al. A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study. Minerva Anestesiol. 2012;78(9):1026-33.
PMID: 22772860

72. Patel J, Baldwin J, Bunting P, Laha S. The effect of a multicomponent multidisciplinary bundle of interventions on sleep and delirium in medical and surgical intensive care patients. Anaesthesia. 2014;69(6):540-9.
DOI: 10.1111/anae.12638
PMID: 24813132

73. Nannapaneni S, Lee SJ, Kashiouris M, Elmer JL, Thakur LK. 2015;34(2):94-100.
DOI: 10.1080/21548331.2015.1015389
PMID: 25687293

74. Alway A, Halm MA, Shilhanek M, St Pierre J. Do earplugs and eye masks affect sleep and delirium outcomes in the critically ill? Am J Crit Care. 2013;22(4):357-60.
DOI: 10.4037/ajcc2013545
PMID: 23817826

75. Taguchi T, Yano M, Kido Y. Influence of bright light therapy on postoperative patients: a pilot study. Intensive Crit Care Nurs. 2007;23(5):289-97.
DOI: 10.1016/j.iccn.2007.04.004
PMID: 17692522

76. Hoyer EH, Friedman M, Lavezza A, Wagner-Kosmakos K, Lewis-Cherry R, Skolnik JL, et al. Promoting mobility and reducing length of stay in hospitalized general medicine patients: A quality-improvement project. J Hosp Med. 2016;11(5):341-7.
DOI: 10.1002/jhm.2546
PMID: 26849277

77. Thompson DR, Hamilton DK, Cadenhead CD, Swoboda SM, Schwindel SM, Anderson DC, et al. Guidelines for intensive care unit design. Crit Care Med. 2012;40(5):1586-600.
DOI: 10.1097/CCM.0b013e3182413bb2
PMID: 22511137

78. Nydahl P, Sricharoenchai T, Chandra S, Kundt FS, Huang M, Fischill M, et al. Safety of patient mobilization and rehabilitation in the intensive care unit. Systematic review with meta-analysis. Ann Am Thorac Soc. 2017;14(5):766-77.
DOI: 10.1513/AnnalsATS.201611-843SR
PMID: 28231030

79. Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911-22.
DOI: 10.1016/S0140-6736(13)60688-1
PMID: 23992774

80. Bregar B, Možgan B.. Posebni varovalni ukrepi – primerjava s tujino. In: Bregar B, Novak JP.. Posebni varovalni ukrepi v teoriji in praksi. Ljubljana: Zbornica zdravstvene in babiške nege Slovenije; Zveza strokovnih društev medicinskih sester, babic in zdravstvenih tehnikov Slovenije; 2012. pp. 13-21.

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2021-06-30

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Professional Article

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1.
Assessment of analgesia, sedation, delirium and sleep disturbance in the intensive care therapy unit and description of non-pharmacological interventions. ZdravVestn [Internet]. 2021 Jun. 30 [cited 2024 Oct. 8];90(5-6):288-306. Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/3055

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