Nanos zdravilnih učinkovin na biokompatibilne podlage z metodo 2D tiskanja za izdelavo farmacevtskih oblik, prilagojenih bolnikom
DOI:
https://doi.org/10.6016/ZdravVestn.3347Ključne besede:
personalizirano zdravljenje, brizgalni tiskalnik, črnila za tiskanje, disperzije nanodelcev, biokompatibilne podlage za tiskanjePovzetek
Pomen personaliziranega načina zdravljenja se iz leta v leto povečuje, saj je zavedanje, da ljudje nismo popolnoma enaki in da vsak organizem potrebuje sebi lastno terapijo, vedno večje. Poznavanje genetike in njenega vpliva na izvor in potek nekaterih bolezni pomen personaliziranega zdravljenja še povečuje. Zato se trenutne raziskave v farmacevtski stroki vedno bolj nagibajo k razvoju in optimizaciji zdravil, ki bi omogočala tak način zdravljenja. V ta namen je dandanes vedno več raziskovalcev, usmerjenih v razvoj nanosa zdravilnih učinkovin (ZU) na podlage z metodo 2D tiskanja, ki zaradi svoje priročnosti, možnosti široke uporabe in enostavnega prilagajanja odmerkov iz dneva v dan pridobiva na vrednosti. Princip tiskanja poteka na enak način kot tiskanje besedilnih dokumentov, le da črnila zamenjamo z disperzijo ZU, medtem ko namesto listov papirja uporabimo različne biološko kompatibilne podlage, ki skupaj z natisnjeno zdravilno učinkovino služijo kot per oralna farmacevtska oblika. Pri tiskanju ZU lahko uporabimo različne vrste tiskalnikov, pri čemer pa vsak izmed njih za uspešno tiskanje zahteva izpolnitev določenih specifikacijskih zahtev. Prednosti, ki jih nanos ZU z metodo 2D tiskanja prinaša, so poleg hitre izdelave personalizirane farmacevtske oblike (FO) z natančnim odmerjanjem tudi hkratno tiskanje in s tem združevanje več ZU hkrati v eno samo FO. Kljub vsemu omenjenemu pa na tem področju še vedno obstaja veliko izzivov, s katerimi se bo potrebno spopasti, preden bo tak način izdelave in odmerjanja zdravil dosegel trg in bil na voljo pacientom.
Prenosi
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