Implementing the »Patient Blood Management« program in everyday clinical practice

Authors

  • Marko Bitenc Surgery Bitenc, Ljubljana, Slovenia
  • Polona Gams Surgery Bitenc, Ljubljana, Slovenia
  • Nenad Danojević Surgery Bitenc, Ljubljana, Slovenia
  • Gregor Hlebič Surgery Bitenc, Ljubljana, Slovenia
  • Aleš Rozman University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia
  • Irena Zupan Department of Haematology, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana
  • Maja Šoštarič, MD, PhD Department of Anaesthesiology and Surgical Intensive Therapy, Division of Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia

DOI:

https://doi.org/10.6016/ZdravVestn.2946

Keywords:

transfusion, preoperative anemia, blood loss, preoperative preparation, hematopoiesis optimisation

Abstract

Transfusion after a surgical procedure elevates risk for perioperative complications, prolongs hospital stay and worsens the outcome of surgical treatment. Undefined and untreated preoperative anaemia presents an independent factor for perioperative complications and transfusion in the perioperative period. Before surgery, we must identify patients at higher risk for anaemia and adjust preoperative preparation, surgical technique and postoperative treatment accordingly.

The “Patient Blood Management” (PBM) programme is established in many European countries and supported by a directorate of the European Commission. It is concerned with the treatment of anemia, optimization of haemostasis and measures to reduce the need for blood transfusion. The three pillars of PBM are: (1) optimal haematopoiesis, (2) reduced iatrogenic blood loss and (3) improved patients’ tolerance for anaemia.

In this article we analyse the proportion of patients that came for surgery to the observed surgical institution in an anaemic state in a two-year period and how many of them needed blood transfusion. We also describe the foundations of the PBM program and a plan to implement it in everyday clinical practice.

Downloads

Download data is not yet available.

Author Biographies

  • Irena Zupan, Department of Haematology, Division of Internal Medicine, University Medical Centre Ljubljana, Ljubljana

    Department of Internal Medicine, Medical Faculty Ljubljana, University of Ljubljana, Ljubljana, Slovenia

  • Maja Šoštarič, MD, PhD, Department of Anaesthesiology and Surgical Intensive Therapy, Division of Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia

    Department of Anaesthesiology and Reanimatology, Medical Faculty Ljubljana, University of Ljubljana, Ljubljana, Slovenia

References

1. Fowler AJ, Ahmad T, Phull MK, Allard S, Gillies MA, Pearse RM. Meta-analysis of the association between preoperative anaemia and mortality after surgery. Br J Surg. 2015;102(11):1314-24.
DOI: 10.1002/bjs.9861
PMID: 26349842

2. Atzil S, Arad M, Glasner A, Abiri N, Avraham R, Greenfeld K, et al. Blood transfusion promotes cancer progression: a critical role for aged erythrocytes. Anesthesiology. 2008;109(6):989-97.
DOI: 10.1097/ALN.0b013e31818ddb72
PMID: 19034095

3. Muñoz M, Gómez-Ramírez S, Campos A, Ruiz J, Liumbruno GM. Pre-operative anaemia: prevalence, consequences and approaches to management. Blood Transfus. 2015;13(3):370-9.
PMID: 26192787

4. Mueller MM, Van Remoortel H, Meybohm P, Aranko K, Aubron C, Burger R, et al.; ICC PBM Frankfurt 2018 Group. Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference. JAMA. 2019;321(10):983-97.
DOI: 10.1001/jama.2019.0554
PMID: 30860564

5. Meybohm P, Richards T, Isbister J, Hofmann A, Shander A, Goodnough LT, et al. Patient Blood Management Bundles to Facilitate Implementation. Transfus Med Rev. 2017;31(1):62-71.
DOI: 10.1016/j.tmrv.2016.05.012
PMID: 27317382

6. Gombotz H, Hofmann A, Norgaard A, Kastner P. Supporting Patient Blood Management (PBM) in the EU - A Practical Implementation Guide for Hospitals 2017. Luxemburg: Publications Office of the European Union; 2017. pp. 3-67.

7. Althoff FC, Neb H, Herrmann E, Trentino KM, Vernich L, Füllenbach C, et al. Multimodal Patient Blood Management Program Based on a Three-pillar Strategy: A Systematic Review and Meta-analysis. Ann Surg. 2019;269(5):794-804.
DOI: 10.1097/SLA.0000000000003095
PMID: 30418206

8. Poženel P, Zver S, Nikolić B, Rožman P. Klinično vodenje transfuzije - sodobni pristopi za optimizacijo transfuzije. Zdrav Vestn. 2015;84(11):743-56.
DOI: 10.6016/ZdravVestn.1357

9. Shander A, Van Aken H, Colomina MJ, Gombotz H, Hofmann A, Krauspe R, et al. Patient blood management in Europe. Br J Anaesth. 2012;109(1):55-68.
DOI: 10.1093/bja/aes139
PMID: 22628393

10. Patel MS, Carson JL. Anemia in the preoperative patient. Anesthesiol Clin. 2009;27(4):751-60.
DOI: 10.1016/j.anclin.2009.09.009
PMID: 19942178

11. WHOHaemoglobin concentrations for the diagnosis of anaemia and assessment of severity. [cited 2019 Jan 20]. Available from: http://www.who.int/vmnis/indicators/haemoglobin.pdf.

12. Muñoz M, Gómez-Ramírez S, Kozek-Langeneker S, Shander A, Richards T, Pavía J, et al. ‘Fit to fly’: overcoming barriers to preoperative haemoglobin optimization in surgical patients. Br J Anaesth. 2015;115(1):15-24.
DOI: 10.1093/bja/aev165
PMID: 26089443

13. Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123(5):615-24.
DOI: 10.1182/blood-2013-06-508325
PMID: 24297872

14. Shander A, Javidroozi M, Ozawa S, Hare GM. What is really dangerous: anaemia or transfusion? Br J Anaesth. 2011;107(1):i41-59.
DOI: 10.1093/bja/aer350
PMID: 22156270

15. Steinbicker AU. Role of anesthesiologists in managing perioperative anemia. Curr Opin Anaesthesiol. 2019;32(1):64-71.
DOI: 10.1097/ACO.0000000000000671
PMID: 30531608

16. Muñoz M, Acheson AG, Auerbach M, Besser M, Habler O, Kehlet H, et al. International consensus statement on the peri-operative management of anaemia and iron deficiency. Anaesthesia. 2017;72(2):233-47.
DOI: 10.1111/anae.13773
PMID: 27996086

17. Alghamdi AA, Albanna MJ, Guru V, Brister SJ. Does the use of erythropoietin reduce the risk of exposure to allogeneic blood transfusion in cardiac surgery? A systematic review and meta-analysis. J Card Surg. 2006;21(3):320-6.
DOI: 10.1111/j.1540-8191.2006.00241.x
PMID: 16684074

18. Wawer AA, Jennings A, Fairweather-Tait SJ. Iron status in the elderly: A review of recent evidence. Mech Ageing Dev. 2018;175:55-73.
DOI: 10.1016/j.mad.2018.07.003
PMID: 30040993

19. Zehnder JL. Clinical use of coagulation tests. [cited 2019 Mar 21]. Available from: https://www.uptodate.com/contents/clinical-use-of-coagulation-tests.

20. Desai N, Schofield N, Richards T. Perioperative patient blood management to improve outcome. Anesth Analg. 2018;127(5):1211-20.
DOI: 10.1213/ANE.0000000000002549
PMID: 29064875

21. Carless PA, Henry DA, Moxey AJ, O’Connell D, Brown T, Fergusson DA. Cell salvage for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2010;17(3):CD001888.
DOI: 10.1002/14651858.CD001888.pub3
PMID: 20238316

22. Whiting D, DiNardo JA. TEG and ROTEM: technology and clinical applications. Am J Hematol. 2014;89(2):228-32.
DOI: 10.1002/ajh.23599
PMID: 24123050

23. Tsai AG, Cabrales P, Intaglietta M. Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions. Transfusion. 2004;44(11):1626-34.
DOI: 10.1111/j.0041-1132.2004.04128.x
PMID: 15504169

24. Padhi S, Kemmis-Betty S, Rajesh S, Hill J, Murphy MF; Guideline Development Group. Blood transfusion: summary of NICE guidance. BMJ. 2015;351:h5832.
DOI: 10.1136/bmj.h5832
PMID: 26581483

25. Preložnik Zupan I. Pomen predoperativne anemije. 21. Schrottovi dnevi. Zbornik predavanj. 16. in 17. marec 2018; Ljubljana. Ljubljana: Medicinski razgledi; 2018.

26. Mavri A, Vene N. Smernice za vodenje antikoagulacijskega zdravljenja. Ljubljana: Slovensko zdravniško društvo; 2009.

27. Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, et al.; Clinical Transfusion Medicine Committee of the AABB. Red blood cell transfusion: a clinical practice guideline from the AABB*. Ann Intern Med. 2012;157(1):49-58.
DOI: 10.7326/0003-4819-157-1-201206190-00429
PMID: 22751760

Published

2020-06-30

How to Cite

1.
Implementing the »Patient Blood Management« program in everyday clinical practice. ZdravVestn [Internet]. 2020 Jun. 30 [cited 2024 Nov. 2];89(5-6):278-86. Available from: https://vestnik.szd.si/index.php/ZdravVest/article/view/2946

Most read articles by the same author(s)

1 2 > >>